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Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.
Jandl K, Stacher E, Bálint Z, Sturm EM, Maric J, Peinhaupt M, Luschnig P, Aringer I, Fauland A, Konya V, Dahlen SE, Wheelock CE, Kratky D, Olschewski A, Marsche G, Schuligoi R, Heinemann A. Jandl K, et al. Among authors: luschnig p. J Allergy Clin Immunol. 2016 Mar;137(3):833-43. doi: 10.1016/j.jaci.2015.11.012. Epub 2016 Jan 12. J Allergy Clin Immunol. 2016. PMID: 26792210 Free PMC article.
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.
Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E. Blättermann S, et al. Among authors: luschnig p. Nat Chem Biol. 2012 Jul;8(7):631-8. doi: 10.1038/nchembio.962. Epub 2012 May 27. Nat Chem Biol. 2012. PMID: 22634634
Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function.
Konya V, Maric J, Jandl K, Luschnig P, Aringer I, Lanz I, Platzer W, Theiler A, Bärnthaler T, Frei R, Marsche G, Marsh LM, Olschewski A, Lippe IT, Heinemann A, Schuligoi R. Konya V, et al. Among authors: luschnig p. Br J Pharmacol. 2015 Sep;172(18):4454-4468. doi: 10.1111/bph.13229. Epub 2015 Jul 31. Br J Pharmacol. 2015. PMID: 26103450 Free PMC article.
12 results