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One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A.
Mancini F, Monaci E, Lofano G, Torre A, Bacconi M, Tavarini S, Sammicheli C, Arcidiacono L, Galletti B, Laera D, Pallaoro M, Tuscano G, Fontana MR, Bensi G, Grandi G, Rossi-Paccani S, Nuti S, Rappuoli R, De Gregorio E, Bagnoli F, Soldaini E, Bertholet S. Mancini F, et al. Among authors: de gregorio e. PLoS One. 2016 Jan 26;11(1):e0147767. doi: 10.1371/journal.pone.0147767. eCollection 2016. PLoS One. 2016. PMID: 26812180 Free PMC article.
Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus.
Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O'Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G. Bagnoli F, et al. Among authors: de gregorio e, de falco mg. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3680-5. doi: 10.1073/pnas.1424924112. Epub 2015 Mar 9. Proc Natl Acad Sci U S A. 2015. PMID: 25775551 Free PMC article.
Four-component Staphylococcus aureus vaccine 4C-staph enhances Fcγ receptor expression in neutrophils and monocytes and mitigates S. aureus infection in neutropenic mice.
Torre A, Bacconi M, Sammicheli C, Galletti B, Laera D, Fontana MR, Grandi G, De Gregorio E, Bagnoli F, Nuti S, Bertholet S, Bensi G. Torre A, et al. Among authors: de gregorio e. Infect Immun. 2015 Aug;83(8):3157-63. doi: 10.1128/IAI.00258-15. Epub 2015 May 26. Infect Immun. 2015. PMID: 26015481 Free PMC article.
MF59- and Al(OH)3-Adjuvanted Staphylococcus aureus (4C-Staph) Vaccines Induce Sustained Protective Humoral and Cellular Immune Responses, with a Critical Role for Effector CD4 T Cells at Low Antibody Titers.
Monaci E, Mancini F, Lofano G, Bacconi M, Tavarini S, Sammicheli C, Arcidiacono L, Giraldi M, Galletti B, Rossi Paccani S, Torre A, Fontana MR, Grandi G, de Gregorio E, Bensi G, Chiarot E, Nuti S, Bagnoli F, Soldaini E, Bertholet S. Monaci E, et al. Among authors: de gregorio e. Front Immunol. 2015 Sep 7;6:439. doi: 10.3389/fimmu.2015.00439. eCollection 2015. Front Immunol. 2015. PMID: 26441955 Free PMC article.
Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination.
Corrado A, Donato P, Maccari S, Cecchi R, Spadafina T, Arcidiacono L, Tavarini S, Sammicheli C, Laera D, Manetti AG, Ruggiero P, Galletti B, Nuti S, De Gregorio E, Bertholet S, Seubert A, Bagnoli F, Bensi G, Chiarot E. Corrado A, et al. Among authors: de gregorio e. Sci Rep. 2016 Nov 30;6:38043. doi: 10.1038/srep38043. Sci Rep. 2016. PMID: 27901071 Free PMC article.
Vaccines for the future: learning from human immunology.
De Gregorio E, Rappuoli R. De Gregorio E, et al. Microb Biotechnol. 2012 Mar;5(2):149-55. doi: 10.1111/j.1751-7915.2011.00276.x. Epub 2011 Aug 31. Microb Biotechnol. 2012. PMID: 21880117 Free PMC article. Review.
Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination.
Lofano G, Mancini F, Salvatore G, Cantisani R, Monaci E, Carrisi C, Tavarini S, Sammicheli C, Rossi Paccani S, Soldaini E, Laera D, Finco O, Nuti S, Rappuoli R, De Gregorio E, Bagnoli F, Bertholet S. Lofano G, et al. Among authors: de gregorio e. J Immunol. 2015 Aug 15;195(4):1617-27. doi: 10.4049/jimmunol.1402604. Epub 2015 Jul 13. J Immunol. 2015. PMID: 26170383
176 results