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The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.
Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P. Stephan G, et al. Among authors: schmalzing g. Nat Commun. 2018 Apr 10;9(1):1354. doi: 10.1038/s41467-018-03728-5. Nat Commun. 2018. PMID: 29636447 Free PMC article.
The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.
Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G. Hausmann R, et al. Among authors: schmalzing g. Mol Pharmacol. 2006 Jun;69(6):2058-67. doi: 10.1124/mol.106.022665. Epub 2006 Mar 21. Mol Pharmacol. 2006. PMID: 16551782
Amino acid residues constituting the agonist binding site of the human P2X3 receptor.
Bodnar M, Wang H, Riedel T, Hintze S, Kato E, Fallah G, Gröger-Arndt H, Giniatullin R, Grohmann M, Hausmann R, Schmalzing G, Illes P, Rubini P. Bodnar M, et al. Among authors: schmalzing g. J Biol Chem. 2011 Jan 28;286(4):2739-49. doi: 10.1074/jbc.M110.167437. Epub 2010 Nov 22. J Biol Chem. 2011. PMID: 21098022 Free PMC article.
121 results