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Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.
Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P. Davies B, et al. Among authors: biggs d. Nature. 2016 Feb 11;530(7589):171-176. doi: 10.1038/nature16931. Epub 2016 Feb 3. Nature. 2016. PMID: 26840484 Free PMC article.
Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.
Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Among authors: biggs d. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713362 Free PMC article.
A versatile transgenic allele for mouse overexpression studies.
Dolatshad H, Biggs D, Diaz R, Hortin N, Preece C, Davies B. Dolatshad H, et al. Among authors: biggs d. Mamm Genome. 2015 Dec;26(11-12):598-608. doi: 10.1007/s00335-015-9602-y. Epub 2015 Sep 14. Mamm Genome. 2015. PMID: 26369329 Free PMC article.
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.
Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Among authors: biggs d. Elife. 2016 Nov 29;5:e19804. doi: 10.7554/eLife.19804. Elife. 2016. PMID: 27897970 Free PMC article.
A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A; WGS500 Consortium; Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC. Davies B, et al. Among authors: biggs d. Hum Mol Genet. 2017 Oct 15;26(20):3869-3882. doi: 10.1093/hmg/ddx270. Hum Mol Genet. 2017. PMID: 29016847 Free PMC article.
241 results