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Mitochondria are required for pro-ageing features of the senescent phenotype.
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Correia-Melo C, et al. EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4. EMBO J. 2016. PMID: 26848154 Free PMC article.
Mitochondria: Are they causal players in cellular senescence?
Correia-Melo C, Passos JF. Correia-Melo C, et al. Biochim Biophys Acta. 2015 Nov;1847(11):1373-9. doi: 10.1016/j.bbabio.2015.05.017. Epub 2015 May 28. Biochim Biophys Acta. 2015. PMID: 26028303 Free article. Review.
Powering senescence: The ugly side of mitochondria.
Correia-Melo C, Birch J, Passos JF. Correia-Melo C, et al. Cell Cycle. 2016 Oct;15(19):2541-2542. doi: 10.1080/15384101.2016.1204852. Epub 2016 Jul 11. Cell Cycle. 2016. PMID: 27399972 Free PMC article. No abstract available.
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Anderson R, et al. EMBO J. 2019 Mar 1;38(5):e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. EMBO J. 2019. PMID: 30737259 Free PMC article.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.
Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Jurk D, et al. Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172. Nat Commun. 2014. PMID: 24960204 Free PMC article.
DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.
Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF. Birch J, et al. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. doi: 10.1152/ajplung.00293.2015. Epub 2015 Sep 18. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 26386121 Free PMC article.
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