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Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Venkatraj M, Ariën KK, Heeres J, Dirié B, Joossens J, Van Goethem S, Van der Veken P, Michiels J, Vande Velde CM, Vanham G, Lewi PJ, Augustyns K. Venkatraj M, et al. Among authors: heeres j. Bioorg Med Chem. 2011 Oct 15;19(20):5924-34. doi: 10.1016/j.bmc.2011.08.060. Epub 2011 Sep 1. Bioorg Med Chem. 2011. PMID: 21930388
Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission.
Ariën KK, Venkatraj M, Michiels J, Joossens J, Vereecken K, Van der Veken P, Abdellati S, Cuylaerts V, Crucitti T, Heyndrickx L, Heeres J, Augustyns K, Lewi PJ, Vanham G. Ariën KK, et al. Among authors: heeres j. J Antimicrob Chemother. 2013 Sep;68(9):2038-47. doi: 10.1093/jac/dkt166. Epub 2013 May 3. J Antimicrob Chemother. 2013. PMID: 23645585
Reverse transcriptase inhibitors as microbicides.
Lewi P, Heeres J, Ariën K, Venkatraj M, Joossens J, Van der Veken P, Augustyns K, Vanham G. Lewi P, et al. Among authors: heeres j. Curr HIV Res. 2012 Jan 1;10(1):27-35. doi: 10.2174/157016212799304643. Curr HIV Res. 2012. PMID: 22264043 Review.
Novel triazine dimers with potent antitrypanosomal activity.
Venkatraj M, Salado IG, Heeres J, Joossens J, Lewi PJ, Caljon G, Maes L, Van der Veken P, Augustyns K. Venkatraj M, et al. Among authors: heeres j. Eur J Med Chem. 2018 Jan 1;143:306-319. doi: 10.1016/j.ejmech.2017.11.075. Epub 2017 Nov 27. Eur J Med Chem. 2018. PMID: 29197735
TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.
Andries K, Azijn H, Thielemans T, Ludovici D, Kukla M, Heeres J, Janssen P, De Corte B, Vingerhoets J, Pauwels R, de Béthune MP. Andries K, et al. Among authors: heeres j. Antimicrob Agents Chemother. 2004 Dec;48(12):4680-6. doi: 10.1128/AAC.48.12.4680-4686.2004. Antimicrob Agents Chemother. 2004. PMID: 15561844 Free PMC article.
60 results