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Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C.
Ulferts R, de Boer SM, van der Linden L, Bauer L, Lyoo HR, Maté MJ, Lichière J, Canard B, Lelieveld D, Omta W, Egan D, Coutard B, van Kuppeveld FJ. Ulferts R, et al. Among authors: bauer l. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2627-38. doi: 10.1128/AAC.02182-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26856848 Free PMC article.
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors.
Manganaro R, Zonsics B, Bauer L, Lorenzo Lopez M, Donselaar T, Zwaagstra M, Saporito F, Ferla S, Strating JRPM, Coutard B, Hurdiss DL, van Kuppeveld FJM, Brancale A. Manganaro R, et al. Among authors: bauer l. Antiviral Res. 2020 Jun;178:104781. doi: 10.1016/j.antiviral.2020.104781. Epub 2020 Mar 29. Antiviral Res. 2020. PMID: 32234539
Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C.
Bauer L, Manganaro R, Zonsics B, Hurdiss DL, Zwaagstra M, Donselaar T, Welter NGE, van Kleef RGDM, Lopez ML, Bevilacqua F, Raman T, Ferla S, Bassetto M, Neyts J, Strating JRPM, Westerink RHS, Brancale A, van Kuppeveld FJM. Bauer L, et al. PLoS Biol. 2020 Nov 6;18(11):e3000904. doi: 10.1371/journal.pbio.3000904. eCollection 2020 Nov. PLoS Biol. 2020. PMID: 33156822 Free PMC article.
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss DL, El Kazzi P, Bauer L, Papageorgiou N, Ferron FP, Donselaar T, van Vliet ALW, Shamorkina TM, Snijder J, Canard B, Decroly E, Brancale A, Zeev-Ben-Mordehai T, Förster F, van Kuppeveld FJM, Coutard B. Hurdiss DL, et al. Among authors: bauer l. Sci Adv. 2022 Jan 7;8(1):eabj7615. doi: 10.1126/sciadv.abj7615. Epub 2022 Jan 5. Sci Adv. 2022. PMID: 34985963 Free PMC article.
Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1.
Sooksawasdi Na Ayudhya S, Meijer A, Bauer L, Oude Munnink B, Embregts C, Leijten L, Siegers JY, Laksono BM, van Kuppeveld F, Kuiken T, Geurts-van Kessel C, van Riel D. Sooksawasdi Na Ayudhya S, et al. Among authors: bauer l. mSphere. 2020 Nov 4;5(6):e00941-20. doi: 10.1128/mSphere.00941-20. mSphere. 2020. PMID: 33148825 Free PMC article.
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses.
Grazia Martina M, Vicenti I, Bauer L, Crespan E, Rango E, Boccuto A, Olivieri N, Incerti M, Zwaagstra M, Allodi M, Bertoni S, Dreassi E, Zazzi M, van Kuppeveld FJM, Maga G, Radi M. Grazia Martina M, et al. Among authors: bauer l. ChemMedChem. 2021 Dec 6;16(23):3548-3552. doi: 10.1002/cmdc.202100483. Epub 2021 Sep 7. ChemMedChem. 2021. PMID: 34382337 Free PMC article.
912 results