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SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.
Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto T, Okabe A, Aburatani H, Li S, Miyoshi I, Takahashi S, Kitagawa M, Nakanishi M. Johmura Y, et al. Among authors: okabe a. Nat Commun. 2016 Feb 12;7:10574. doi: 10.1038/ncomms10574. Nat Commun. 2016. PMID: 26868148 Free PMC article.
Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.
Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H. Tsuchiya N, et al. Among authors: okabe a. Cancer Res. 2011 Jul 1;71(13):4628-39. doi: 10.1158/0008-5472.CAN-10-2475. Epub 2011 May 12. Cancer Res. 2011. PMID: 21565979 Free PMC article.
PHLDA1, another PHLDA family protein that inhibits Akt.
Chen Y, Takikawa M, Tsutsumi S, Yamaguchi Y, Okabe A, Shimada M, Kawase T, Sada A, Ezawa I, Takano Y, Nagata K, Suzuki Y, Semba K, Aburatani H, Ohki R. Chen Y, et al. Among authors: okabe a. Cancer Sci. 2018 Nov;109(11):3532-3542. doi: 10.1111/cas.13796. Epub 2018 Oct 13. Cancer Sci. 2018. PMID: 30207029 Free PMC article.
TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.
Shirai K, Nagae G, Seki M, Kudo Y, Kamio A, Hayashi A, Okabe A, Ota S, Tsutsumi S, Fujita T, Yamamoto S, Nakaki R, Kanki Y, Osawa T, Midorikawa Y, Tateishi K, Ichinose M, Aburatani H. Shirai K, et al. Among authors: okabe a. Cancer Sci. 2021 Jul;112(7):2855-2869. doi: 10.1111/cas.14897. Epub 2021 May 10. Cancer Sci. 2021. PMID: 33970549 Free PMC article.
254 results