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An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity.
Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S. Kondo Y, et al. Among authors: iwao t. Drug Metab Pharmacokinet. 2014;29(3):237-43. doi: 10.2133/dmpk.dmpk-13-rg-104. Epub 2013 Dec 10. Drug Metab Pharmacokinet. 2014. PMID: 24334537 Free PMC article.
Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
Kondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T. Kondo Y, et al. Among authors: iwao t. PLoS One. 2014 Aug 1;9(8):e104010. doi: 10.1371/journal.pone.0104010. eCollection 2014. PLoS One. 2014. PMID: 25084468 Free PMC article.
Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into enterocytes.
Kodama N, Iwao T, Kabeya T, Horikawa T, Niwa T, Kondo Y, Nakamura K, Matsunaga T. Kodama N, et al. Among authors: iwao t. Drug Metab Pharmacokinet. 2016 Jun;31(3):193-200. doi: 10.1016/j.dmpk.2016.02.002. Epub 2016 Feb 17. Drug Metab Pharmacokinet. 2016. PMID: 27161454
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.
Takenaka T, Kazuki K, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T, Abe S, Oshimura M, Kazuki Y. Takenaka T, et al. Among authors: iwao t. Drug Metab Pharmacokinet. 2017 Feb;32(1):61-68. doi: 10.1016/j.dmpk.2016.08.004. Epub 2016 Aug 26. Drug Metab Pharmacokinet. 2017. PMID: 28139373
237 results