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Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.
Lu H, Kopcho L, Ghosh K, Witmer M, Parker M, Gupta S, Paul M, Krishnamurthy P, Laksmaiah B, Xie D, Tredup J, Zhang L, Abell LM. Lu H, et al. Among authors: zhang l. Anal Biochem. 2016 May 15;501:56-65. doi: 10.1016/j.ab.2016.02.003. Epub 2016 Feb 11. Anal Biochem. 2016. PMID: 26874021
Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.
Chaudhry C, Davis J, Zhang Y, Posy S, Lei M, Shen H, Yan C, Devaux B, Zhang L, Blat Y, Metzler W, Borzilleri RM, Talbott RL. Chaudhry C, et al. Among authors: zhang l, zhang y. Anal Biochem. 2016 Mar 15;497:8-17. doi: 10.1016/j.ab.2015.11.026. Epub 2015 Dec 30. Anal Biochem. 2016. PMID: 26743718
A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.
Seethala R, Golla R, Ma Z, Zhang H, O'Malley K, Lippy J, Cheng L, Mookhtiar K, Farrelly D, Zhang L, Hariharan N, Cheng PT. Seethala R, et al. Among authors: zhang l, zhang h. Anal Biochem. 2007 Apr 15;363(2):263-74. doi: 10.1016/j.ab.2007.01.022. Epub 2007 Jan 28. Anal Biochem. 2007. PMID: 17335769
GPCR assay automation for leveraging lead optimization.
Cvijic ME, Chen J, Kubala S, Nolfo J, Kolodin G, Zhang L. Cvijic ME, et al. Among authors: zhang l. J Lab Autom. 2012 Aug;17(4):266-74. doi: 10.1177/2211068212442502. Epub 2012 Apr 13. J Lab Autom. 2012. PMID: 22505604
A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton's Tyrosine Kinase.
Ong LL, Vasta JD, Monereau L, Locke G, Ribeiro H, Pattoli MA, Skala S, Burke JR, Watterson SH, Tino JA, Meisenheimer PL, Arey B, Lippy J, Zhang L, Robers MB, Tebben A, Chaudhry C. Ong LL, et al. Among authors: zhang l. SLAS Discov. 2020 Feb;25(2):176-185. doi: 10.1177/2472555219884881. Epub 2019 Nov 9. SLAS Discov. 2020. PMID: 31709883 Free article.
Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening.
Ogawa LM, Burford NT, Liao YH, Scott CE, Hine AM, Dowling C, Chin J, Power M, Hunnicutt EJ Jr, Emerick VL, Banks M, Zhang L, Gerritz SW, Alt A, Kendall DA. Ogawa LM, et al. Among authors: zhang l. SLAS Discov. 2018 Apr;23(4):375-383. doi: 10.1177/2472555217748403. Epub 2017 Dec 19. SLAS Discov. 2018. PMID: 29257918 Free PMC article.
135,266 results
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