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Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology.
Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B. Felka T, et al. Among authors: rothdiener m. Osteoarthritis Cartilage. 2016 Jul;24(7):1200-9. doi: 10.1016/j.joca.2016.02.001. Epub 2016 Feb 12. Osteoarthritis Cartilage. 2016. PMID: 26879798 Free PMC article.
Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment.
Rolauffs B, Kurz B, Felka T, Rothdiener M, Uynuk-Ool T, Aurich M, Frank E, Bahrs C, Badke A, Stöckle U, Aicher WK, Grodzinsky AJ. Rolauffs B, et al. Among authors: rothdiener m. J Struct Biol. 2013 Sep;183(3):501-511. doi: 10.1016/j.jsb.2013.06.011. Epub 2013 Jun 28. J Struct Biol. 2013. PMID: 23810923 Free PMC article.
The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.
Uynuk-Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, Seeger T, Stöckle U, Stegemann JP, Aicher WK, Kurz B, Hart ML, Klein G, Rolauffs B. Uynuk-Ool T, et al. Among authors: rothdiener m. J Tissue Eng Regen Med. 2017 Dec;11(12):3508-3522. doi: 10.1002/term.2263. Epub 2017 Mar 29. J Tissue Eng Regen Med. 2017. PMID: 28371409 Free article.
12 results