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Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly.
Xu X, Godoy-Ruiz R, Adipietro KA, Peralta C, Ben-Hail D, Varney KM, Cook ME, Roth BM, Wilder PT, Cleveland T, Grishaev A, Neu HM, Michel SLJ, Yu W, Beckett D, Rustandi RR, Lancaster C, Loughney JW, Kristopeit A, Christanti S, Olson JW, MacKerell AD, Georges AD, Pozharski E, Weber DJ. Xu X, et al. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1049-1058. doi: 10.1073/pnas.1919490117. Epub 2020 Jan 2. Proc Natl Acad Sci U S A. 2020. PMID: 31896582 Free PMC article.
Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors.
Conlon IL, Van Eker D, Abdelmalak S, Murphy WA, Bashir H, Sun M, Chauhan J, Varney KM, Godoy-Ruiz R, Wilder PT, Fletcher S. Conlon IL, et al. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1949-1953. doi: 10.1016/j.bmcl.2018.03.050. Epub 2018 Mar 26. Bioorg Med Chem Lett. 2018. PMID: 29705141
Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival.
Kerr C, Szmacinski H, Fisher ML, Nance B, Lakowicz JR, Akbar A, Keillor JW, Lok Wong T, Godoy-Ruiz R, Toth EA, Weber DJ, Eckert RL. Kerr C, et al. Oncogene. 2017 May 25;36(21):2981-2990. doi: 10.1038/onc.2016.452. Epub 2016 Dec 12. Oncogene. 2017. PMID: 27941875 Free PMC article.
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