Chen CS - Search Results

1

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function.

Booth L, Shuch B, Albers T, Roberts JL, Tavallai M, Proniuk S, Zukiwski A, Wang D, Chen CS, Bottaro D, Ecroyd H, Lebedyeva IO, Dent P. Booth L, et al. Among authors: chen cs. Oncotarget. 2016 Mar 15;7(11):12975-96. doi: 10.18632/oncotarget.7349. Oncotarget. 2016. PMID: 26887051 Free PMC article.

2

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing.

Booth L, Cazanave SC, Hamed HA, Yacoub A, Ogretmen B, Chen CS, Grant S, Dent P. Booth L, et al. Among authors: chen cs. Cancer Biol Ther. 2012 Feb 15;13(4):224-36. doi: 10.4161/cbt.13.4.18877. Cancer Biol Ther. 2012. PMID: 22354011 Free PMC article.

3

OSU-03012 interacts with lapatinib to kill brain cancer cells.

Booth L, Cruickshanks N, Ridder T, Chen CS, Grant S, Dent P. Booth L, et al. Among authors: chen cs. Cancer Biol Ther. 2012 Dec;13(14):1501-11. doi: 10.4161/cbt.22275. Epub 2012 Sep 18. Cancer Biol Ther. 2012. PMID: 22990204 Free PMC article.

4

PERK-dependent regulation of HSP70 expression and the regulation of autophagy.

Park MA, Curiel DT, Koumenis C, Graf M, Chen CS, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: chen cs. Autophagy. 2008 Apr;4(3):364-7. doi: 10.4161/auto.5593. Epub 2008 Jan 17. Autophagy. 2008. PMID: 18216498

5

OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.

Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: chen cs. Mol Pharmacol. 2008 Apr;73(4):1168-84. doi: 10.1124/mol.107.042697. Epub 2008 Jan 8. Mol Pharmacol. 2008. PMID: 18182481 Free PMC article.

6

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins.

Hamed HA, Yacoub A, Park MA, Eulitt P, Sarkar D, Dimitrie IP, Chen CS, Grant S, Curiel DT, Fisher PB, Dent P. Hamed HA, et al. Among authors: chen cs. Cancer Biol Ther. 2010 Apr 1;9(7):526-36. doi: 10.4161/cbt.9.7.11116. Epub 2010 Apr 1. Cancer Biol Ther. 2010. PMID: 20107314 Free PMC article.

7

Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor.

Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Weng SC, et al. Among authors: chen cs. Mol Cancer Ther. 2008 Apr;7(4):800-8. doi: 10.1158/1535-7163.MCT-07-0434. Mol Cancer Ther. 2008. Retraction in: Mol Cancer Ther. 2019 Apr;18(4):869. doi: 10.1158/1535-7163.MCT-19-0151 PMID: 18413793 Retracted.

8

OSU03012 activates Erk1/2 and Cdks leading to the accumulation of cells in the S-phase and apoptosis.

Ding H, Han C, Guo D, Wang D, Chen CS, D'Ambrosio SM. Ding H, et al. Among authors: chen cs. Int J Cancer. 2008 Dec 15;123(12):2923-30. doi: 10.1002/ijc.23896. Int J Cancer. 2008. PMID: 18798257

9

OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells.

Yacoub A, Park MA, Hanna D, Hong Y, Mitchell C, Pandya AP, Harada H, Powis G, Chen CS, Koumenis C, Grant S, Dent P. Yacoub A, et al. Among authors: chen cs. Mol Pharmacol. 2006 Aug;70(2):589-603. doi: 10.1124/mol.106.025007. Epub 2006 Apr 18. Mol Pharmacol. 2006. PMID: 16622074

10

Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors.

Wang YC, Kulp SK, Wang D, Yang CC, Sargeant AM, Hung JH, Kashida Y, Yamaguchi M, Chang GD, Chen CS. Wang YC, et al. Among authors: chen cs. Cancer Res. 2008 Apr 15;68(8):2820-30. doi: 10.1158/0008-5472.CAN-07-1336. Cancer Res. 2008. PMID: 18413750 Free PMC article.

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