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7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.
Kaniakova M, Kleteckova L, Lichnerova K, Holubova K, Skrenkova K, Korinek M, Krusek J, Smejkalova T, Korabecny J, Vales K, Soukup O, Horak M. Kaniakova M, et al. Among authors: kleteckova l. Neuropharmacology. 2018 Sep 15;140:217-232. doi: 10.1016/j.neuropharm.2018.08.010. Epub 2018 Aug 9. Neuropharmacology. 2018. PMID: 30099049
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K. Chalupova K, et al. Among authors: kleteckova l. Eur J Med Chem. 2019 Apr 15;168:491-514. doi: 10.1016/j.ejmech.2019.02.021. Epub 2019 Feb 27. Eur J Med Chem. 2019. PMID: 30851693
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.
Kaniakova M, Korabecny J, Holubova K, Kleteckova L, Chvojkova M, Hakenova K, Prchal L, Novak M, Dolezal R, Hepnarova V, Svobodova B, Kucera T, Lichnerova K, Krausova B, Horak M, Vales K, Soukup O. Kaniakova M, et al. Among authors: kleteckova l. Biochem Pharmacol. 2021 Apr;186:114460. doi: 10.1016/j.bcp.2021.114460. Epub 2021 Feb 8. Biochem Pharmacol. 2021. PMID: 33571502
16 results