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Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.
Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M. Sunami Y, et al. Among authors: wirth t. Hepatology. 2016 May;63(5):1592-607. doi: 10.1002/hep.28435. Epub 2016 Mar 4. Hepatology. 2016. PMID: 26892811 Free article.
Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation.
Sunami Y, Leithäuser F, Gul S, Fiedler K, Güldiken N, Espenlaub S, Holzmann KH, Hipp N, Sindrilaru A, Luedde T, Baumann B, Wissel S, Kreppel F, Schneider M, Scharffetter-Kochanek K, Kochanek S, Strnad P, Wirth T. Sunami Y, et al. Among authors: wirth t. Hepatology. 2012 Sep;56(3):1117-28. doi: 10.1002/hep.25711. Epub 2012 Jul 10. Hepatology. 2012. PMID: 22407857
Intestinal carcinogenesis: IKK can go all the way.
Sunami Y, Wirth T. Sunami Y, et al. Among authors: wirth t. J Clin Invest. 2011 Jul;121(7):2551-3. doi: 10.1172/JCI58454. Epub 2011 Jun 23. J Clin Invest. 2011. PMID: 21701071 Free PMC article.
Myc regulates embryonic vascular permeability and remodeling.
Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leithäuser F, Schmidt V, Deutsch U, Wirth T. Kokai E, et al. Among authors: wirth t. Circ Res. 2009 May 22;104(10):1151-9. doi: 10.1161/CIRCRESAHA.108.191460. Epub 2009 Apr 30. Circ Res. 2009. PMID: 19407242
FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.
Xie L, Ushmorov A, Leithäuser F, Guan H, Steidl C, Färbinger J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, Möller P, Wirth T. Xie L, et al. Among authors: wirth t. Blood. 2012 Apr 12;119(15):3503-11. doi: 10.1182/blood-2011-09-381905. Epub 2012 Feb 17. Blood. 2012. PMID: 22343918 Free article.
703 results