Labaudinière R - Search Results

1

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis.

Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. Coelho T, et al. Among authors: labaudiniere r. Neurol Ther. 2016 Jun;5(1):1-25. doi: 10.1007/s40120-016-0040-x. Epub 2016 Feb 19. Neurol Ther. 2016. PMID: 26894299 Free PMC article. Review.

2

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Bulawa CE, et al. Among authors: labaudiniere r. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34. doi: 10.1073/pnas.1121005109. Epub 2012 May 29. Proc Natl Acad Sci U S A. 2012. PMID: 22645360 Free PMC article.

3

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial.

Coelho T, Maia LF, Martins da Silva A, Waddington Cruz M, Planté-Bordeneuve V, Lozeron P, Suhr OB, Campistol JM, Conceição IM, Schmidt HH, Trigo P, Kelly JW, Labaudinière R, Chan J, Packman J, Wilson A, Grogan DR. Coelho T, et al. Among authors: labaudiniere r. Neurology. 2012 Aug 21;79(8):785-92. doi: 10.1212/WNL.0b013e3182661eb1. Epub 2012 Jul 25. Neurology. 2012. PMID: 22843282 Free PMC article. Clinical Trial.

4

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy.

Coelho T, Maia LF, da Silva AM, Cruz MW, Planté-Bordeneuve V, Suhr OB, Conceiçao I, Schmidt HH, Trigo P, Kelly JW, Labaudinière R, Chan J, Packman J, Grogan DR. Coelho T, et al. Among authors: labaudiniere r. J Neurol. 2013 Nov;260(11):2802-14. doi: 10.1007/s00415-013-7051-7. Epub 2013 Aug 22. J Neurol. 2013. PMID: 23974642 Free PMC article. Clinical Trial.

5

A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction.

Jiang X, Labaudinière R, Buxbaum JN, Monteiro C, Novais M, Coelho T, Kelly JW. Jiang X, et al. Among authors: labaudiniere r. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2016072118. doi: 10.1073/pnas.2016072118. Proc Natl Acad Sci U S A. 2021. PMID: 33597308 Free PMC article.

6

Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis.

Sun S, Wang C, Zhao P, Kline GM, Grandjean JMD, Jiang X, Labaudiniere R, Wiseman RL, Kelly JW, Balch WE. Sun S, et al. Among authors: labaudiniere r. Cell Chem Biol. 2023 Jan 19;30(1):22-42.e5. doi: 10.1016/j.chembiol.2022.12.004. Epub 2023 Jan 10. Cell Chem Biol. 2023. PMID: 36630963 Free PMC article.

7

The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.

Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Linget JM, Kirilovsky J, Hyafil F, Labaudinière R. Daugan A, et al. Among authors: labaudiniere r. J Med Chem. 2003 Oct 9;46(21):4533-42. doi: 10.1021/jm0300577. J Med Chem. 2003. PMID: 14521415

8

The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.

Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Kirilovsky J, Hyafil F, Labaudinière R. Daugan A, et al. Among authors: labaudiniere r. J Med Chem. 2003 Oct 9;46(21):4525-32. doi: 10.1021/jm030056e. J Med Chem. 2003. PMID: 14521414

9

The increasing importance of genetic variation in drug discovery and development.

Labaudinière R. Labaudinière R. Curr Opin Mol Ther. 2002 Dec;4(6):559-64. Curr Opin Mol Ther. 2002. PMID: 12596357 Review.

10

Analogues of human parathyroid hormone (1-31)NH(2): further evaluation of the effect of conformational constraint on biological activity.

Condon SM, Darnbrough S, Burns CJ, Bobko MA, Morize I, Uhl J, Jariwala NU, Burke K, Labaudiniere RF. Condon SM, et al. Among authors: labaudiniere rf. Bioorg Med Chem. 2002 Mar;10(3):731-6. doi: 10.1016/s0968-0896(01)00335-2. Bioorg Med Chem. 2002. PMID: 11814862

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