ElHady AK - Search Results

1

Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.

Ahmed NS, Elghazawy NH, ElHady AK, Engel M, Hartmann RW, Abadi AH. Ahmed NS, et al. Among authors: elhady ak. Eur J Med Chem. 2016 Apr 13;112:171-179. doi: 10.1016/j.ejmech.2016.02.026. Epub 2016 Feb 9. Eur J Med Chem. 2016. PMID: 26896706

2

Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK, Engel M. Abdel-Halim M, et al. Among authors: elhady ak. Eur J Pharm Sci. 2016 Oct 10;93:405-9. doi: 10.1016/j.ejps.2016.08.016. Epub 2016 Aug 8. Eur J Pharm Sci. 2016. PMID: 27516147

3

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.

Elhady AK, Sigler SC, Noureldin N, Canzoneri JC, Ahmed NS, Piazza GA, Abadi AH. Elhady AK, et al. Sci Pharm. 2015 Sep 26;84(3):428-446. doi: 10.3390/scipharm84030428. Sci Pharm. 2015. PMID: 28117310 Free PMC article.

4

Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.

ElHady AK, Abdel-Halim M, Abadi AH, Engel M. ElHady AK, et al. J Med Chem. 2017 Jul 13;60(13):5377-5391. doi: 10.1021/acs.jmedchem.6b01915. Epub 2017 May 31. J Med Chem. 2017. PMID: 28561591

5

Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification.

Darwish SS, Abdel-Halim M, ElHady AK, Salah M, Abadi AH, Becker W, Engel M. Darwish SS, et al. Among authors: elhady ak. Eur J Med Chem. 2018 Oct 5;158:270-285. doi: 10.1016/j.ejmech.2018.08.097. Epub 2018 Sep 3. Eur J Med Chem. 2018. PMID: 30223116

6

Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors.

ElHady AK, Shih SP, Chen YC, Liu YC, Ahmed NS, Keeton AB, Piazza GA, Engel M, Abadi AH, Abdel-Halim M. ElHady AK, et al. Bioorg Chem. 2020 May;98:103742. doi: 10.1016/j.bioorg.2020.103742. Epub 2020 Mar 10. Bioorg Chem. 2020. PMID: 32199305

7

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency.

ElHady AK, El-Gamil DS, Chen PJ, Hwang TL, Abadi AH, Abdel-Halim M, Engel M. ElHady AK, et al. Molecules. 2021 Feb 13;26(4):1001. doi: 10.3390/molecules26041001. Molecules. 2021. PMID: 33668683 Free PMC article.

8

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.

AlNajjar YT, Gabr M, ElHady AK, Salah M, Wilms G, Abadi AH, Becker W, Abdel-Halim M, Engel M. AlNajjar YT, et al. Among authors: elhady ak. Eur J Med Chem. 2022 Jan 5;227:113911. doi: 10.1016/j.ejmech.2021.113911. Epub 2021 Oct 9. Eur J Med Chem. 2022. PMID: 34710745

9

Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.

Aboushady Y, Gabr M, ElHady AK, Salah M, Abadi AH, Wilms G, Becker W, Abdel-Halim M, Engel M. Aboushady Y, et al. Among authors: elhady ak. ACS Chem Neurosci. 2021 Nov 17;12(22):4302-4318. doi: 10.1021/acschemneuro.1c00475. Epub 2021 Nov 2. ACS Chem Neurosci. 2021. PMID: 34726394

10

Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker.

El-Gamil DS, ElHady AK, Chen PJ, Hwang TL, Abadi AH, Abdel-Halim M, Engel M. El-Gamil DS, et al. Among authors: elhady ak. Eur J Med Chem. 2022 Aug 5;238:114411. doi: 10.1016/j.ejmech.2022.114411. Epub 2022 Apr 26. Eur J Med Chem. 2022. PMID: 35635953

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