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Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy.
O'Cochlain DF, Perez-Terzic C, Reyes S, Kane GC, Behfar A, Hodgson DM, Strommen JA, Liu XK, van den Broek W, Wansink DG, Wieringa B, Terzic A. O'Cochlain DF, et al. Among authors: wieringa b. Hum Mol Genet. 2004 Oct 15;13(20):2505-18. doi: 10.1093/hmg/ddh266. Epub 2004 Aug 18. Hum Mol Genet. 2004. PMID: 15317754
Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy.
Mulders SA, van den Broek WJ, Wheeler TM, Croes HJ, van Kuik-Romeijn P, de Kimpe SJ, Furling D, Platenburg GJ, Gourdon G, Thornton CA, Wieringa B, Wansink DG. Mulders SA, et al. Among authors: wieringa b. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13915-20. doi: 10.1073/pnas.0905780106. Epub 2009 Aug 10. Proc Natl Acad Sci U S A. 2009. PMID: 19667189 Free PMC article.
Cell membrane integrity in myotonic dystrophy type 1: implications for therapy.
González-Barriga A, Kranzen J, Croes HJ, Bijl S, van den Broek WJ, van Kessel ID, van Engelen BG, van Deutekom JC, Wieringa B, Mulders SA, Wansink DG. González-Barriga A, et al. Among authors: wieringa b. PLoS One. 2015 Mar 23;10(3):e0121556. doi: 10.1371/journal.pone.0121556. eCollection 2015. PLoS One. 2015. PMID: 25799359 Free PMC article.
CRISPR/Cas9-Induced (CTG⋅CAG)n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing.
van Agtmaal EL, André LM, Willemse M, Cumming SA, van Kessel IDG, van den Broek WJAA, Gourdon G, Furling D, Mouly V, Monckton DG, Wansink DG, Wieringa B. van Agtmaal EL, et al. Among authors: wieringa b. Mol Ther. 2017 Jan 4;25(1):24-43. doi: 10.1016/j.ymthe.2016.10.014. Epub 2017 Jan 4. Mol Ther. 2017. PMID: 28129118 Free PMC article.
279 results