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A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification.
Xu B, Deng Y, Bi R, Guo H, Shu C, Shah NK, Chang J, Liu G, Du Y, Wei W, Wang C. Xu B, et al. Among authors: wei w. Cancer Chemother Pharmacol. 2018 Jun;81(6):1083-1093. doi: 10.1007/s00280-018-3582-z. Epub 2018 Apr 17. Cancer Chemother Pharmacol. 2018. PMID: 29667067
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