Stubbs KA - Search Results

1

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases.

Hattie M, Cekic N, Debowski AW, Vocadlo DJ, Stubbs KA. Hattie M, et al. Among authors: stubbs ka. Org Biomol Chem. 2016 Mar 28;14(12):3193-7. doi: 10.1039/c6ob00297h. Org Biomol Chem. 2016. PMID: 26924385 Free article.

2

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis.

Macauley MS, Stubbs KA, Vocadlo DJ. Macauley MS, et al. Among authors: stubbs ka. J Am Chem Soc. 2005 Dec 14;127(49):17202-3. doi: 10.1021/ja0567687. J Am Chem Soc. 2005. PMID: 16332065

3

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides.

Stubbs KA, Macauley MS, Vocadlo DJ. Stubbs KA, et al. Carbohydr Res. 2006 Jul 24;341(10):1764-9. doi: 10.1016/j.carres.2005.12.009. Epub 2006 Feb 10. Carbohydr Res. 2006. PMID: 16472788

4

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

Stubbs KA, Zhang N, Vocadlo DJ. Stubbs KA, et al. Org Biomol Chem. 2006 Mar 7;4(5):839-45. doi: 10.1039/b516273d. Epub 2006 Jan 18. Org Biomol Chem. 2006. PMID: 16493467

5

Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.

Cetinbaş N, Macauley MS, Stubbs KA, Drapala R, Vocadlo DJ. Cetinbaş N, et al. Among authors: stubbs ka. Biochemistry. 2006 Mar 21;45(11):3835-44. doi: 10.1021/bi052370b. Biochemistry. 2006. PMID: 16533067

6

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.

Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ. Dennis RJ, et al. Among authors: stubbs ka. Nat Struct Mol Biol. 2006 Apr;13(4):365-71. doi: 10.1038/nsmb1079. Epub 2006 Mar 26. Nat Struct Mol Biol. 2006. PMID: 16565725

7

Functional proteomic profiling of glycan-processing enzymes.

Stubbs KA, Vocadlo DJ. Stubbs KA, et al. Methods Enzymol. 2006;415:253-68. doi: 10.1016/S0076-6879(06)15016-8. Methods Enzymol. 2006. PMID: 17116479

8

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Whitworth GE, et al. Among authors: stubbs ka. J Am Chem Soc. 2007 Jan 24;129(3):635-44. doi: 10.1021/ja065697o. J Am Chem Soc. 2007. PMID: 17227027

9

Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance.

Stubbs KA, Balcewich M, Mark BL, Vocadlo DJ. Stubbs KA, et al. J Biol Chem. 2007 Jul 20;282(29):21382-91. doi: 10.1074/jbc.M700084200. Epub 2007 Apr 16. J Biol Chem. 2007. PMID: 17439950 Free article.

10

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases.

Scaffidi A, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Vocadlo DJ, Stick RV. Scaffidi A, et al. Among authors: stubbs ka. Org Biomol Chem. 2007 Sep 21;5(18):3013-9. doi: 10.1039/b709681j. Epub 2007 Aug 15. Org Biomol Chem. 2007. PMID: 17728868

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