Shelkovnikova T - Search Results

1

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L. Scekic-Zahirovic J, et al. Among authors: shelkovnikova t. EMBO J. 2016 May 17;35(10):1077-97. doi: 10.15252/embj.201592559. Epub 2016 Mar 7. EMBO J. 2016. PMID: 26951610 Free PMC article.

2

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.

Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN. Shelkovnikova TA, et al. J Biol Chem. 2013 Aug 30;288(35):25266-25274. doi: 10.1074/jbc.M113.492017. Epub 2013 Jul 18. J Biol Chem. 2013. PMID: 23867462 Free PMC article.

3

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm.

Shelkovnikova TA, Robinson HK, Connor-Robson N, Buchman VL. Shelkovnikova TA, et al. Cell Cycle. 2013 Oct 1;12(19):3194-202. doi: 10.4161/cc.26241. Epub 2013 Sep 4. Cell Cycle. 2013. PMID: 24013423 Free PMC article.

4

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis.

Shelkovnikova TA, An H, Skelt L, Tregoning JS, Humphreys IR, Buchman VL. Shelkovnikova TA, et al. Cell Rep. 2019 Dec 24;29(13):4496-4508.e4. doi: 10.1016/j.celrep.2019.11.094. Cell Rep. 2019. PMID: 31875556 Free PMC article.

5

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles.

An H, Skelt L, Notaro A, Highley JR, Fox AH, La Bella V, Buchman VL, Shelkovnikova TA. An H, et al. Acta Neuropathol Commun. 2019 Jan 14;7(1):7. doi: 10.1186/s40478-019-0658-x. Acta Neuropathol Commun. 2019. PMID: 30642400 Free PMC article.

6

[A mice model of amyotrophic lateral sclerosis expressing mutant human FUS protein].

Deĭkin AV, Kovrazhkina EA, Ovchinnikov RK, Bronovitskiĭ EV, Razinskaia OD, Smirnov AP, Ermolkevich TG, Eliakov AB, Popov AN, Fedorov EN, Lytkina OA, Kukharskiĭ MS, Tarasova TV, Shelkovnikova TA, Ustiugov AA, Ninkina NN, Gol'dman IL, Sadchikova ER, Bachurin SO, Skvortsova VI. Deĭkin AV, et al. Among authors: shelkovnikova ta. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(8):62-9. Zh Nevrol Psikhiatr Im S S Korsakova. 2014. PMID: 25345633 Russian.

7

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS.

An H, Rabesahala de Meritens C, Buchman VL, Shelkovnikova TA. An H, et al. Mol Brain. 2020 May 13;13(1):77. doi: 10.1186/s13041-020-00618-0. Mol Brain. 2020. PMID: 32404191 Free PMC article.

8

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis.

Peters OM, Millership S, Shelkovnikova TA, Soto I, Keeling L, Hann A, Marsh-Armstrong N, Buchman VL, Ninkina N. Peters OM, et al. Neurobiol Dis. 2012 Oct;48(1):124-31. doi: 10.1016/j.nbd.2012.06.016. Epub 2012 Jun 30. Neurobiol Dis. 2012. PMID: 22750530 Free PMC article.

9

Compromised paraspeckle formation as a pathogenic factor in FUSopathies.

Shelkovnikova TA, Robinson HK, Troakes C, Ninkina N, Buchman VL. Shelkovnikova TA, et al. Hum Mol Genet. 2014 May 1;23(9):2298-312. doi: 10.1093/hmg/ddt622. Epub 2013 Dec 11. Hum Mol Genet. 2014. PMID: 24334610 Free PMC article.

10

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity.

An H, Litscher G, Watanabe N, Wei W, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. An H, et al. Among authors: shelkovnikova ta. Neurobiol Dis. 2022 Jan;162:105585. doi: 10.1016/j.nbd.2021.105585. Epub 2021 Dec 14. Neurobiol Dis. 2022. PMID: 34915152 Free PMC article.

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