Pearson JA - Search Results

1

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

Pearson JA, Thayer TC, McLaren JE, Ladell K, De Leenheer E, Phillips A, Davies J, Kakabadse D, Miners K, Morgan P, Wen L, Price DA, Wong FS. Pearson JA, et al. Diabetes. 2016 Jun;65(6):1679-89. doi: 10.2337/db15-1498. Epub 2016 Mar 7. Diabetes. 2016. PMID: 26953160 Free PMC article.

2

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.

Motozono C, Pearson JA, De Leenheer E, Rizkallah PJ, Beck K, Trimby A, Sewell AK, Wong FS, Cole DK. Motozono C, et al. Among authors: pearson ja. J Biol Chem. 2015 Jul 31;290(31):18924-33. doi: 10.1074/jbc.M114.622522. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085090 Free PMC article.

3

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.

Hu C, Ding H, Li Y, Pearson JA, Zhang X, Flavell RA, Wong FS, Wen L. Hu C, et al. Among authors: pearson ja. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11318-23. doi: 10.1073/pnas.1513509112. Epub 2015 Aug 24. Proc Natl Acad Sci U S A. 2015. PMID: 26305961 Free PMC article.

4

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.

Pearson JA, Wong FS, Wen L. Pearson JA, et al. J Autoimmun. 2016 Jan;66:76-88. doi: 10.1016/j.jaut.2015.08.019. Epub 2015 Sep 26. J Autoimmun. 2016. PMID: 26403950 Free PMC article. Review.

5

Identification of Islet Antigen-Specific CD8 T Cells Using MHCI-Peptide Tetramer Reagents in the Non Obese Diabetic (NOD) Mouse Model of Type 1 Diabetes.

Pearson JA, Wong FS. Pearson JA, et al. Methods Mol Biol. 2016;1433:119-25. doi: 10.1007/7651_2015_295. Methods Mol Biol. 2016. PMID: 26659799

6

Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes.

Thayer TC, Pearson JA, De Leenheer E, Hanna SJ, Boldison J, Davies J, Tsui A, Ahmed S, Easton P, Siew LK, Wen L, Wong FS. Thayer TC, et al. Among authors: pearson ja. Diabetes. 2016 Nov;65(11):3429-3439. doi: 10.2337/db15-1649. Epub 2016 Aug 5. Diabetes. 2016. PMID: 27495224

7

Targeted suppression of autoreactive CD8⁺ T-cell activation using blocking anti-CD8 antibodies.

Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L. Clement M, et al. Among authors: pearson ja. Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332. Sci Rep. 2016. PMID: 27748447 Free PMC article.

8

Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.

Li YY, Pearson JA, Chao C, Peng J, Zhang X, Zhou Z, Liu Y, Wong FS, Wen L. Li YY, et al. Among authors: pearson ja. J Autoimmun. 2017 Aug;82:85-95. doi: 10.1016/j.jaut.2017.05.007. Epub 2017 Jun 4. J Autoimmun. 2017. PMID: 28592385 Free PMC article.

9

Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice.

Tan Q, Tai N, Li Y, Pearson J, Pennetti S, Zhou Z, Wong FS, Wen L. Tan Q, et al. JCI Insight. 2018 Jan 11;3(1):e95882. doi: 10.1172/jci.insight.95882. eCollection 2018 Jan 11. JCI Insight. 2018. PMID: 29321370 Free PMC article.

10

Cyclophosphamide-modified murine peritoneal macrophages induce CD4⁺ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression.

Majewska-Szczepanik M, Kowalczyk P, Biała D, Marcińska K, Strzępa A, Woźniak D, Sura P, Pearson J, Wen L, Szczepanik M. Majewska-Szczepanik M, et al. Pharmacol Rep. 2018 Aug;70(4):796-803. doi: 10.1016/j.pharep.2018.02.015. Epub 2018 Feb 23. Pharmacol Rep. 2018. PMID: 29957340

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