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Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.
Kooij V, Viswanathan MC, Lee DI, Rainer PP, Schmidt W, Kronert WA, Harding SE, Kass DA, Bernstein SI, Van Eyk JE, Cammarato A. Kooij V, et al. Among authors: schmidt w. Cardiovasc Res. 2016 May 15;110(2):238-48. doi: 10.1093/cvr/cvw050. Epub 2016 Mar 7. Cardiovasc Res. 2016. PMID: 26956799 Free PMC article.
Fropofol decreases force development in cardiac muscle.
Ren X, Schmidt W, Huang Y, Lu H, Liu W, Bu W, Eckenhoff R, Cammarato A, Gao WD. Ren X, et al. Among authors: schmidt w. FASEB J. 2018 Aug;32(8):4203-4213. doi: 10.1096/fj.201701442R. Epub 2018 Mar 9. FASEB J. 2018. PMID: 29522375 Free PMC article.
From a clinical standpoint, these findings are particularly significant, given that fropofol is a nonanesthetic small molecule that decreases myocardial contractility specifically and thus may be useful in the treatment of hypercontractile cardiac disorders.-Ren, X., Schmidt …
From a clinical standpoint, these findings are particularly significant, given that fropofol is a nonanesthetic small molecule that decrease …
TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction.
Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. Madan A, et al. Among authors: schmidt w. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18822-18831. doi: 10.1073/pnas.2001692117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690703 Free PMC article.
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[No authors listed] [No authors listed] PMID: 36783383
3,532 results