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An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies.
O'Neil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, Li J, Kral A, Lejnine S, Loboda A, Arthur W, Cristescu R, Haines BB, Winter C, Zhang T, Bloecher A, Shumway SD. O'Neil J, et al. Among authors: li j. Mol Cancer Ther. 2016 Jun;15(6):1155-62. doi: 10.1158/1535-7163.MCT-15-0843. Epub 2016 Mar 16. Mol Cancer Ther. 2016. PMID: 26983881
Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy.
Guertin AD, Li J, Liu Y, Hurd MS, Schuller AG, Long B, Hirsch HA, Feldman I, Benita Y, Toniatti C, Zawel L, Fawell SE, Gilliland DG, Shumway SD. Guertin AD, et al. Among authors: li j. Mol Cancer Ther. 2013 Aug;12(8):1442-52. doi: 10.1158/1535-7163.MCT-13-0025. Epub 2013 May 22. Mol Cancer Ther. 2013. PMID: 23699655
Endogenous Locus Reporter Assays.
Liu Y, Hermes J, Li J, Tudor M. Liu Y, et al. Among authors: li j. Methods Mol Biol. 2018;1755:163-177. doi: 10.1007/978-1-4939-7724-6_12. Methods Mol Biol. 2018. PMID: 29671270
Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background.
Davies BR, Greenwood H, Dudley P, Crafter C, Yu DH, Zhang J, Li J, Gao B, Ji Q, Maynard J, Ricketts SA, Cross D, Cosulich S, Chresta CC, Page K, Yates J, Lane C, Watson R, Luke R, Ogilvie D, Pass M. Davies BR, et al. Among authors: li j. Mol Cancer Ther. 2012 Apr;11(4):873-87. doi: 10.1158/1535-7163.MCT-11-0824-T. Epub 2012 Jan 31. Mol Cancer Ther. 2012. PMID: 22294718 Clinical Trial.
Parsimonious discovery of synergistic drug combinations.
Severyn B, Liehr RA, Wolicki A, Nguyen KH, Hudak EM, Ferrer M, Caldwell JS, Hermes JD, Li J, Tudor M. Severyn B, et al. Among authors: li j. ACS Chem Biol. 2011 Dec 16;6(12):1391-8. doi: 10.1021/cb2003225. Epub 2011 Oct 19. ACS Chem Biol. 2011. PMID: 21974780
High-Content Reporter Assays.
Cook E, Hermes J, Li J, Tudor M. Cook E, et al. Among authors: li j. Methods Mol Biol. 2018;1755:179-195. doi: 10.1007/978-1-4939-7724-6_13. Methods Mol Biol. 2018. PMID: 29671271
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Bukhtiyarova M, Cook EM, Hancock PJ, Hruza AW, Shaw AW, Adam GC, Barnard RJO, McKenna PM, Holloway MK, Bell IM, Carroll S, Cornella-Taracido I, Cox CD, Kutchukian PS, Powell DA, Strickland C, Trotter BW, Tudor M, Wolkenberg S, Li J, Tellers DM. Bukhtiyarova M, et al. Among authors: li j. ACS Med Chem Lett. 2020 Dec 23;12(1):99-106. doi: 10.1021/acsmedchemlett.0c00551. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488970 Free PMC article.
Translatability: what does it mean in drug discovery?
Tudor M, Hermes J, Li J. Tudor M, et al. Among authors: li j. Drug Discov Today. 2016 Jun;21(6):865-7. doi: 10.1016/j.drudis.2016.03.010. Epub 2016 Mar 26. Drug Discov Today. 2016. PMID: 27021791 No abstract available.
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