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Activating mutations in c-KIT and PDGFRalpha are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes.
Burger H, den Bakker MA, Kros JM, van Tol H, de Bruin AM, Oosterhuis W, van den Ingh HF, van der Harst E, de Schipper HP, Wiemer EA, Nooter K. Burger H, et al. Among authors: wiemer ea. Cancer Biol Ther. 2005 Nov;4(11):1270-4. doi: 10.4161/cbt.4.11.2253. Epub 2005 Nov 18. Cancer Biol Ther. 2005. PMID: 16294026 Free article.
Renal function as a predictor of irinotecan-induced neutropenia.
de Jong FA, van der Bol JM, Mathijssen RH, van Gelder T, Wiemer EA, Sparreboom A, Verweij J. de Jong FA, et al. Among authors: wiemer ea. Clin Pharmacol Ther. 2008 Aug;84(2):254-62. doi: 10.1038/sj.clpt.6100513. Epub 2008 Feb 20. Clin Pharmacol Ther. 2008. PMID: 18288083
The spliceosome as target for anticancer treatment.
van Alphen RJ, Wiemer EA, Burger H, Eskens FA. van Alphen RJ, et al. Among authors: wiemer ea. Br J Cancer. 2009 Jan 27;100(2):228-32. doi: 10.1038/sj.bjc.6604801. Epub 2008 Nov 25. Br J Cancer. 2009. PMID: 19034274 Free PMC article. Review.
Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry.
de Bruijn P, Moghaddam-Helmantel IM, de Jonge MJ, Meyer T, Lam MH, Verweij J, Wiemer EA, Loos WJ. de Bruijn P, et al. J Pharm Biomed Anal. 2009 Dec 5;50(5):977-82. doi: 10.1016/j.jpba.2009.06.048. Epub 2009 Jul 7. J Pharm Biomed Anal. 2009. PMID: 19628352
153 results