Quan H - Search Results

1

Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo.

Wang W, Liu Y, Zhao Z, Xie C, Xu Y, Hu Y, Quan H, Lou L. Wang W, et al. Among authors: quan h. Cancer Sci. 2016 Jun;107(6):782-90. doi: 10.1111/cas.12934. Epub 2016 Apr 27. Cancer Sci. 2016. PMID: 27002306 Free PMC article.

2

p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.

Quan H, Xu Y, Lou L. Quan H, et al. Int J Cancer. 2008 Apr 15;122(8):1730-7. doi: 10.1002/ijc.23262. Int J Cancer. 2008. PMID: 18074350

3

YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo.

Tian S, Quan H, Xie C, Guo H, Lü F, Xu Y, Li J, Lou L. Tian S, et al. Among authors: quan h. Cancer Sci. 2011 Jul;102(7):1374-80. doi: 10.1111/j.1349-7006.2011.01939.x. Epub 2011 May 9. Cancer Sci. 2011. PMID: 21443688 Free PMC article. Clinical Trial.

4

YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance.

Zhao H, Quan H, Xie C, Xu Y, Xie F, Hu Y, Lou L. Zhao H, et al. Among authors: quan h. Cancer Lett. 2012 Jan 1;314(1):54-62. doi: 10.1016/j.canlet.2011.09.013. Epub 2011 Sep 19. Cancer Lett. 2012. PMID: 21982683

5

RON confers lapatinib resistance in HER2-positive breast cancer cells.

Wang Q, Quan H, Zhao J, Xie C, Wang L, Lou L. Wang Q, et al. Among authors: quan h. Cancer Lett. 2013 Oct 28;340(1):43-50. doi: 10.1016/j.canlet.2013.06.022. Epub 2013 Jun 27. Cancer Lett. 2013. PMID: 23811285

6

Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants.

Zhao J, Quan H, Xu Y, Kong X, Jin L, Lou L. Zhao J, et al. Among authors: quan h. Cancer Sci. 2014 Jan;105(1):117-25. doi: 10.1111/cas.12320. Epub 2014 Jan 4. Cancer Sci. 2014. PMID: 24205792 Free PMC article.

7

Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition.

Sun L, Quan H, Xie C, Wang L, Hu Y, Lou L. Sun L, et al. Among authors: quan h. PLoS One. 2014 Mar 5;9(3):e90627. doi: 10.1371/journal.pone.0090627. eCollection 2014. PLoS One. 2014. PMID: 24598942 Free PMC article.

8

X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response.

Zhao Z, Zhu J, Quan H, Wang G, Li B, Zhu W, Xie C, Lou L. Zhao Z, et al. Among authors: quan h. Oncotarget. 2016 May 17;7(20):29648-63. doi: 10.18632/oncotarget.8818. Oncotarget. 2016. PMID: 27105490 Free PMC article.

9

Aberrant intracellular metabolism of T-DM1 confers T-DM1 resistance in human epidermal growth factor receptor 2-positive gastric cancer cells.

Wang H, Wang W, Xu Y, Yang Y, Chen X, Quan H, Lou L. Wang H, et al. Among authors: quan h. Cancer Sci. 2017 Jul;108(7):1458-1468. doi: 10.1111/cas.13253. Epub 2017 May 23. Cancer Sci. 2017. PMID: 28388007 Free PMC article.

10

Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor.

Xie C, Wan X, Quan H, Zheng M, Fu L, Li Y, Lou L. Xie C, et al. Among authors: quan h. Cancer Sci. 2018 Apr;109(4):1207-1219. doi: 10.1111/cas.13536. Epub 2018 Mar 25. Cancer Sci. 2018. PMID: 29446853 Free PMC article.

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