Abell C - Search Results

1

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.

Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Kavanagh ME, et al. Among authors: abell c. J Med Chem. 2016 Apr 14;59(7):3272-302. doi: 10.1021/acs.jmedchem.6b00007. Epub 2016 Mar 22. J Med Chem. 2016. PMID: 27002486 Free PMC article.

2

Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.

Toscano MD, Frederickson M, Evans DP, Coggins JR, Abell C, González-Bello C. Toscano MD, et al. Among authors: abell c. Org Biomol Chem. 2003 Jun 21;1(12):2075-83. doi: 10.1039/b301731a. Org Biomol Chem. 2003. PMID: 12945898

3

(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases.

Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C. Frederickson M, et al. Among authors: abell c. Org Biomol Chem. 2004 Jun 7;2(11):1592-6. doi: 10.1039/b404535a. Epub 2004 May 6. Org Biomol Chem. 2004. PMID: 15162210

4

Rational design of new bifunctional inhibitors of type II dehydroquinase.

Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C. Toscano MD, et al. Among authors: abell c. Org Biomol Chem. 2005 Sep 7;3(17):3102-4. doi: 10.1039/b507156a. Epub 2005 Aug 1. Org Biomol Chem. 2005. PMID: 16106291

5

Design and synthesis of aromatic inhibitors of anthranilate synthase.

Payne RJ, Bulloch EM, Abell AD, Abell C. Payne RJ, et al. Among authors: abell ad, abell c. Org Biomol Chem. 2005 Oct 21;3(20):3629-35. doi: 10.1039/b510633h. Epub 2005 Sep 9. Org Biomol Chem. 2005. PMID: 16211099

6

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Howard N, et al. Among authors: abell c. J Med Chem. 2006 Feb 23;49(4):1346-55. doi: 10.1021/jm050850v. J Med Chem. 2006. PMID: 16480269

7

Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.

Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Ciulli A, et al. Among authors: abell c. J Med Chem. 2006 Aug 10;49(16):4992-5000. doi: 10.1021/jm060490r. J Med Chem. 2006. PMID: 16884311

8

Fragment-based approaches to enzyme inhibition.

Ciulli A, Abell C. Ciulli A, et al. Among authors: abell c. Curr Opin Biotechnol. 2007 Dec;18(6):489-96. doi: 10.1016/j.copbio.2007.09.003. Epub 2007 Oct 24. Curr Opin Biotechnol. 2007. PMID: 17959370 Free PMC article. Review.

9

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Hung AW, et al. Among authors: abell c. Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821. Angew Chem Int Ed Engl. 2009. PMID: 19780086 No abstract available.

10

A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.

Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A. Scott DE, et al. Among authors: abell c. Chembiochem. 2009 Nov 23;10(17):2772-9. doi: 10.1002/cbic.200900537. Chembiochem. 2009. PMID: 19827080 Free PMC article.

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