Surade S - Search Results

1

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.

Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Kavanagh ME, et al. Among authors: surade s. J Med Chem. 2016 Apr 14;59(7):3272-302. doi: 10.1021/acs.jmedchem.6b00007. Epub 2016 Mar 22. J Med Chem. 2016. PMID: 27002486 Free PMC article.

2

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121.

Hudson SA, McLean KJ, Surade S, Yang YQ, Leys D, Ciulli A, Munro AW, Abell C. Hudson SA, et al. Among authors: surade s. Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9311-6. doi: 10.1002/anie.201202544. Epub 2012 Aug 13. Angew Chem Int Ed Engl. 2012. PMID: 22890978 No abstract available.

3

Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121.

Hudson SA, Surade S, Coyne AG, McLean KJ, Leys D, Munro AW, Abell C. Hudson SA, et al. Among authors: surade s. ChemMedChem. 2013 Sep;8(9):1451-6. doi: 10.1002/cmdc.201300219. Epub 2013 Jun 20. ChemMedChem. 2013. PMID: 23788280 Free PMC article.

4

A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR.

Surade S, Ty N, Hengrung N, Lechartier B, Cole ST, Abell C, Blundell TL. Surade S, et al. Biochem J. 2014 Mar 1;458(2):387-94. doi: 10.1042/BJ20131127. Biochem J. 2014. PMID: 24313835

5

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.

Nikiforov PO, Surade S, Blaszczyk M, Delorme V, Brodin P, Baulard AR, Blundell TL, Abell C. Nikiforov PO, et al. Among authors: surade s. Org Biomol Chem. 2016 Feb 21;14(7):2318-26. doi: 10.1039/c5ob02630j. Epub 2016 Jan 25. Org Biomol Chem. 2016. PMID: 26806381 Free PMC article.

6

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.

Nikiforov PO, Blaszczyk M, Surade S, Boshoff HI, Sajid A, Delorme V, Deboosere N, Brodin P, Baulard AR, Barry CE 3rd, Blundell TL, Abell C. Nikiforov PO, et al. Among authors: surade s. ACS Chem Biol. 2017 May 19;12(5):1390-1396. doi: 10.1021/acschembio.7b00091. Epub 2017 Apr 5. ACS Chem Biol. 2017. PMID: 28314097 Free PMC article.

7

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.

Luciani R, Saxena P, Surade S, Santucci M, Venturelli A, Borsari C, Marverti G, Ponterini G, Ferrari S, Blundell TL, Costi MP. Luciani R, et al. Among authors: surade s. J Med Chem. 2016 Oct 13;59(19):9269-9275. doi: 10.1021/acs.jmedchem.6b00977. Epub 2016 Sep 29. J Med Chem. 2016. PMID: 27589670 Free article.

8

Structural biology and drug discovery of difficult targets: the limits of ligandability.

Surade S, Blundell TL. Surade S, et al. Chem Biol. 2012 Jan 27;19(1):42-50. doi: 10.1016/j.chembiol.2011.12.013. Chem Biol. 2012. PMID: 22284353 Review.

9

The complex mechanism of antimycobacterial action of 5-fluorouracil.

Singh V, Brecik M, Mukherjee R, Evans JC, Svetlíková Z, Blaško J, Surade S, Blackburn J, Warner DF, Mikušová K, Mizrahi V. Singh V, et al. Among authors: surade s. Chem Biol. 2015 Jan 22;22(1):63-75. doi: 10.1016/j.chembiol.2014.11.006. Epub 2014 Dec 24. Chem Biol. 2015. PMID: 25544046

10

Heterologous production and functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin.

Goswami D, Kaur J, Surade S, Grell E, Michel H. Goswami D, et al. Among authors: surade s. Biol Chem. 2012 Jul;393(7):617-29. doi: 10.1515/hsz-2012-0101. Biol Chem. 2012. PMID: 22944666

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