Nordlund P - Search Results

1

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P. Almqvist H, et al. Among authors: nordlund p. Nat Commun. 2016 Mar 24;7:11040. doi: 10.1038/ncomms11040. Nat Commun. 2016. PMID: 27010513 Free PMC article.

2

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P. Martinez Molina D, et al. Among authors: nordlund p. Science. 2013 Jul 5;341(6141):84-7. doi: 10.1126/science.1233606. Science. 2013. PMID: 23828940

3

The cellular thermal shift assay for evaluating drug target interactions in cells.

Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundbäck T, Nordlund P, Martinez Molina D. Jafari R, et al. Among authors: nordlund p. Nat Protoc. 2014 Sep;9(9):2100-22. doi: 10.1038/nprot.2014.138. Epub 2014 Aug 7. Nat Protoc. 2014. PMID: 25101824

4

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.

Martinez Molina D, Nordlund P. Martinez Molina D, et al. Among authors: nordlund p. Annu Rev Pharmacol Toxicol. 2016;56:141-61. doi: 10.1146/annurev-pharmtox-010715-103715. Epub 2015 Nov 9. Annu Rev Pharmacol Toxicol. 2016. PMID: 26566155 Review.

5

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.

Chen D, Jansson A, Sim D, Larsson A, Nordlund P. Chen D, et al. Among authors: nordlund p. J Biol Chem. 2017 Aug 11;292(32):13449-13458. doi: 10.1074/jbc.M117.787267. Epub 2017 Jun 20. J Biol Chem. 2017. PMID: 28634233 Free PMC article.

6

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.

Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggström JZ, Nordlund P. Martinez Molina D, et al. Among authors: nordlund p. Nature. 2007 Aug 2;448(7153):613-6. doi: 10.1038/nature06009. Epub 2007 Jul 15. Nature. 2007. PMID: 17632546

7

Efficiency of hit generation and structural characterization in fragment-based ligand discovery.

Larsson A, Jansson A, Åberg A, Nordlund P. Larsson A, et al. Among authors: nordlund p. Curr Opin Chem Biol. 2011 Aug;15(4):482-8. doi: 10.1016/j.cbpa.2011.06.008. Epub 2011 Jul 1. Curr Opin Chem Biol. 2011. PMID: 21724447 Review.

8

Catalysis within the lipid bilayer-structure and mechanism of the MAPEG family of integral membrane proteins.

Martinez Molina D, Eshaghi S, Nordlund P. Martinez Molina D, et al. Among authors: nordlund p. Curr Opin Struct Biol. 2008 Aug;18(4):442-9. doi: 10.1016/j.sbi.2008.04.005. Epub 2008 Jun 12. Curr Opin Struct Biol. 2008. PMID: 18550357

9

Tracking cancer drugs in living cells by thermal profiling of the proteome.

Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G. Savitski MM, et al. Among authors: nordlund p. Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2. Science. 2014. PMID: 25278616

10

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.

Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, Ghosh S, Epstein DM, Dymock BW, Lee SH. Kitagawa M, et al. Among authors: nordlund p. Nat Commun. 2017 Dec 19;8(1):2200. doi: 10.1038/s41467-017-02287-5. Nat Commun. 2017. PMID: 29259156 Free PMC article.

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