Arnold ME - Search Results

1

Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics.

Zheng N, Zeng J, Manney A, Williams L, Aubry AF, Voronin K, Buzescu A, Zhang YJ, Allentoff A, Xu C, Shen H, Warner W, Arnold ME. Zheng N, et al. Among authors: arnold me. Anal Chim Acta. 2016 Apr 15;916:42-51. doi: 10.1016/j.aca.2016.02.017. Epub 2016 Feb 20. Anal Chim Acta. 2016. PMID: 27016437

2

Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.

Zheng N, Fung EN, Buzescu A, Arnold ME, Zeng J. Zheng N, et al. Among authors: arnold me. Rapid Commun Mass Spectrom. 2012 Jun 15;26(11):1291-304. doi: 10.1002/rcm.6230. Rapid Commun Mass Spectrom. 2012. PMID: 22555922

3

Simple and efficient digestion of a monoclonal antibody in serum using pellet digestion: comparison with traditional digestion methods in LC-MS/MS bioanalysis.

Yuan L, Arnold ME, Aubry AF, Ji QC. Yuan L, et al. Among authors: arnold me. Bioanalysis. 2012 Dec;4(24):2887-96. doi: 10.4155/bio.12.284. Bioanalysis. 2012. PMID: 23244280

4

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

Zheng N, Zeng J, Akinsanya B, Buzescu A, Xia YQ, Ly V, Trouba K, Peng Q, Aubry AF, Arnold ME. Zheng N, et al. Among authors: arnold me. J Pharm Biomed Anal. 2013 Sep;83:237-48. doi: 10.1016/j.jpba.2013.05.019. Epub 2013 May 20. J Pharm Biomed Anal. 2013. PMID: 23770636

5

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang H, Zeng J, Titsch C, Voronin K, Akinsanya B, Luo L, Shen H, Desai DD, Allentoff A, Aubry AF, Desilva BS, Arnold ME. Jiang H, et al. Among authors: arnold me. Anal Chem. 2013 Oct 15;85(20):9859-67. doi: 10.1021/ac402420v. Epub 2013 Sep 26. Anal Chem. 2013. PMID: 24024648

6

Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

Zheng N, Zeng J, Ji QC, Angeles A, Buzescu A, Basdeo S, Aubry AF, Trouba K, Patrone LM, Peng Q, Arnold ME. Zheng N, et al. Among authors: arnold me. J Pharm Biomed Anal. 2014 Feb;89:240-50. doi: 10.1016/j.jpba.2013.11.017. Epub 2013 Nov 19. J Pharm Biomed Anal. 2014. PMID: 24316424

7

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

Jiang H, Xu W, Titsch CA, Furlong MT, Dodge R, Voronin K, Allentoff A, Zeng J, Aubry AF, DeSilva BS, Arnold ME. Jiang H, et al. Among authors: arnold me. Anal Chem. 2014 Mar 4;86(5):2673-80. doi: 10.1021/ac5001465. Epub 2014 Feb 17. Anal Chem. 2014. PMID: 24506335

8

Feasibility assessment of a novel selective peptide derivatization strategy for sensitivity enhancement for the liquid chromatography/tandem mass spectrometry bioanalysis of protein therapeutics in serum.

Yuan L, Mai A, Aubry AF, Arnold ME, Ji QC. Yuan L, et al. Among authors: arnold me. Rapid Commun Mass Spectrom. 2014 Apr 15;28(7):705-12. doi: 10.1002/rcm.6836. Rapid Commun Mass Spectrom. 2014. PMID: 24573801

9

Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target.

Gong C, Zeng J, Akinsanya B, Jiang H, Mora J, Chilewski S, Gambardella J, Allentoff A, Gleason C, Aubry AF, DeSilva BS, Arnold ME. Gong C, et al. Among authors: arnold me. Bioanalysis. 2014 Sep;6(18):2371-83. doi: 10.4155/bio.14.181. Bioanalysis. 2014. PMID: 25384590

10

"Center punch" and "whole spot" bioanalysis of apixaban in human dried blood spot samples by UHPLC-MS/MS.

Zheng N, Yuan L, Ji QC, Mangus H, Song Y, Frost C, Zeng J, Aubry AF, Arnold ME. Zheng N, et al. Among authors: arnold me. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:66-74. doi: 10.1016/j.jchromb.2015.02.023. Epub 2015 Feb 21. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25746754

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