Smith M - Search Results

1

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.

Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. Deans RM, et al. Among authors: smith m. Nat Chem Biol. 2016 May;12(5):361-6. doi: 10.1038/nchembio.2050. Epub 2016 Mar 28. Nat Chem Biol. 2016. PMID: 27018887 Free PMC article.

2

PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma.

Tan X, Banerjee P, Pham EA, Rutaganira FUN, Basu K, Bota-Rabassedas N, Guo HF, Grzeskowiak CL, Liu X, Yu J, Shi L, Peng DH, Rodriguez BL, Zhang J, Zheng V, Duose DY, Solis LM, Mino B, Raso MG, Behrens C, Wistuba II, Scott KL, Smith M, Nguyen K, Lam G, Choong I, Mazumdar A, Hill JL, Gibbons DL, Brown PH, Russell WK, Shokat K, Creighton CJ, Glenn JS, Kurie JM. Tan X, et al. Among authors: smith m. Sci Transl Med. 2020 Jan 22;12(527):eaax3772. doi: 10.1126/scitranslmed.aax3772. Sci Transl Med. 2020. PMID: 31969487 Free PMC article.

3

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism.

Liu Q, Gupta A, Okesli-Armlovich A, Qiao W, Fischer CR, Smith M, Carette JE, Bassik MC, Khosla C. Liu Q, et al. Among authors: smith m. Cell Chem Biol. 2020 Jun 18;27(6):668-677.e9. doi: 10.1016/j.chembiol.2020.05.002. Epub 2020 May 21. Cell Chem Biol. 2020. PMID: 32442424 Free PMC article.

4

Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity.

Carozza JA, Böhnert V, Nguyen KC, Skariah G, Shaw KE, Brown JA, Rafat M, von Eyben R, Graves EE, Glenn JS, Smith M, Li L. Carozza JA, et al. Among authors: smith m. Nat Cancer. 2020 Feb;1(2):184-196. doi: 10.1038/s43018-020-0028-4. Epub 2020 Feb 24. Nat Cancer. 2020. PMID: 33768207 Free PMC article.

5

Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells.

Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Horton TM, et al. Among authors: smith m. Cell Chem Biol. 2019 Feb 21;26(2):213-222.e6. doi: 10.1016/j.chembiol.2018.10.019. Epub 2018 Dec 6. Cell Chem Biol. 2019. PMID: 30527998 Free PMC article.

6

Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP.

Carozza JA, Brown JA, Böhnert V, Fernandez D, AlSaif Y, Mardjuki RE, Smith M, Li L. Carozza JA, et al. Among authors: smith m. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5. doi: 10.1016/j.chembiol.2020.07.007. Epub 2020 Jul 28. Cell Chem Biol. 2020. PMID: 32726585 Free PMC article.

7

Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics.

Karbasi AB, Barfuss JD, Morgan TC, Collins D, Costenbader DA, Dennis DG, Hinman A, Ko K, Messina C, Nguyen KC, Schugar RC, Stein KA, Williams BB, Xu H, Annes JP, Smith M. Karbasi AB, et al. Among authors: smith m. Nat Commun. 2024 Oct 1;15(1):8487. doi: 10.1038/s41467-024-52793-6. Nat Commun. 2024. PMID: 39353935 Free PMC article.

8

Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters.

Mitton B, Hsu K, Dutta R, Tiu BC, Cox N, McLure KG, Chae HD, Smith M, Eklund EA, Solow-Cordero DE, Sakamoto KM. Mitton B, et al. Among authors: smith m. Oncotarget. 2016 Feb 23;7(8):8653-62. doi: 10.18632/oncotarget.7085. Oncotarget. 2016. PMID: 26840025 Free PMC article.

9

Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation.

Cox N, Kintzing JR, Smith M, Grant GA, Cochran JR. Cox N, et al. Among authors: smith m. Angew Chem Int Ed Engl. 2016 Aug 16;55(34):9894-7. doi: 10.1002/anie.201603488. Epub 2016 Jun 15. Angew Chem Int Ed Engl. 2016. PMID: 27304709 Free PMC article.

10

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization.

Allegretti PA, Horton TM, Abdolazimi Y, Moeller HP, Yeh B, Caffet M, Michel G, Smith M, Annes JP. Allegretti PA, et al. Among authors: smith m. Bioorg Med Chem. 2020 Jan 1;28(1):115193. doi: 10.1016/j.bmc.2019.115193. Epub 2019 Nov 11. Bioorg Med Chem. 2020. PMID: 31757680 Free PMC article.

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