Sargent DJ - Search Results

1

New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation study.

Bayar MA, Le Teuff G, Michiels S, Sargent DJ, Le Deley MC. Bayar MA, et al. Among authors: sargent dj. Stat Med. 2016 Aug 30;35(19):3245-58. doi: 10.1002/sim.6942. Epub 2016 Mar 30. Stat Med. 2016. PMID: 27027783

2

An adaptive phase I design for identifying a biologically optimal dose for dual agent drug combinations.

Mandrekar SJ, Cui Y, Sargent DJ. Mandrekar SJ, et al. Among authors: sargent dj. Stat Med. 2007 May 20;26(11):2317-30. doi: 10.1002/sim.2707. Stat Med. 2007. PMID: 17016867

3

Progression-free survival is a surrogate for survival in advanced colorectal cancer.

Buyse M, Burzykowski T, Carroll K, Michiels S, Sargent DJ, Miller LL, Elfring GL, Pignon JP, Piedbois P. Buyse M, et al. Among authors: sargent dj. J Clin Oncol. 2007 Nov 20;25(33):5218-24. doi: 10.1200/JCO.2007.11.8836. J Clin Oncol. 2007. PMID: 18024867

4

Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials.

Sargent D, Sobrero A, Grothey A, O'Connell MJ, Buyse M, Andre T, Zheng Y, Green E, Labianca R, O'Callaghan C, Seitz JF, Francini G, Haller D, Yothers G, Goldberg R, de Gramont A. Sargent D, et al. J Clin Oncol. 2009 Feb 20;27(6):872-7. doi: 10.1200/JCO.2008.19.5362. Epub 2009 Jan 5. J Clin Oncol. 2009. PMID: 19124803 Free PMC article.

5

Clinical trial designs for predictive biomarker validation: one size does not fit all.

Mandrekar SJ, Sargent DJ. Mandrekar SJ, et al. Among authors: sargent dj. J Biopharm Stat. 2009;19(3):530-42. doi: 10.1080/10543400902802458. J Biopharm Stat. 2009. PMID: 19384694 Free PMC article.

6

Current issues in oncology drug development, with a focus on Phase II trials.

Sargent DJ, Taylor JM. Sargent DJ, et al. J Biopharm Stat. 2009;19(3):556-62. doi: 10.1080/10543400902802474. J Biopharm Stat. 2009. PMID: 19384696 Free PMC article.

7

Importance of randomization in early clinical trials.

Sargent D. Sargent D. Clin Adv Hematol Oncol. 2009 Apr;7(4):249-51. Clin Adv Hematol Oncol. 2009. PMID: 19521327 No abstract available.

8

Comparison of error rates in single-arm versus randomized phase II cancer clinical trials.

Tang H, Foster NR, Grothey A, Ansell SM, Goldberg RM, Sargent DJ. Tang H, et al. Among authors: sargent dj. J Clin Oncol. 2010 Apr 10;28(11):1936-41. doi: 10.1200/JCO.2009.25.5489. Epub 2010 Mar 8. J Clin Oncol. 2010. PMID: 20212253 Free PMC article.

9

Predictive biomarker validation in practice: lessons from real trials.

Mandrekar SJ, Sargent DJ. Mandrekar SJ, et al. Among authors: sargent dj. Clin Trials. 2010 Oct;7(5):567-73. doi: 10.1177/1740774510368574. Epub 2010 Apr 14. Clin Trials. 2010. PMID: 20392785 Free PMC article.

10

Model-based phase I designs incorporating toxicity and efficacy for single and dual agent drug combinations: methods and challenges.

Mandrekar SJ, Qin R, Sargent DJ. Mandrekar SJ, et al. Among authors: sargent dj. Stat Med. 2010 May 10;29(10):1077-83. doi: 10.1002/sim.3706. Stat Med. 2010. PMID: 20419760 Free PMC article.

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