Schoeberl B - Search Results

1

HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B.

Kirouac DC, Du J, Lahdenranta J, Onsum MD, Nielsen UB, Schoeberl B, McDonagh CF. Kirouac DC, et al. Among authors: schoeberl b. PLoS Comput Biol. 2016 Apr 1;12(4):e1004827. doi: 10.1371/journal.pcbi.1004827. eCollection 2016 Apr. PLoS Comput Biol. 2016. PMID: 27035903 Free PMC article.

2

Systems biology and combination therapy in the quest for clinical efficacy.

Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK. Fitzgerald JB, et al. Among authors: schoeberl b. Nat Chem Biol. 2006 Sep;2(9):458-66. doi: 10.1038/nchembio817. Nat Chem Biol. 2006. PMID: 16921358

3

A data-driven computational model of the ErbB receptor signaling network.

Schoeberl B, Pace E, Howard S, Garantcharova V, Kudla A, Sorger PK, Nielsen UB. Schoeberl B, et al. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:53-4. doi: 10.1109/IEMBS.2006.259754. Conf Proc IEEE Eng Med Biol Soc. 2006. PMID: 17946779

4

Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.

Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Chen WW, et al. Among authors: schoeberl b. Mol Syst Biol. 2009;5:239. doi: 10.1038/msb.2008.74. Epub 2009 Jan 20. Mol Syst Biol. 2009. PMID: 19156131 Free PMC article.

5

Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L, Linggi B, Kalra A, Paragas V, Bukhalid R, Grantcharova V, Kohli N, West KA, Leszczyniecka M, Feldhaus MJ, Kudla AJ, Nielsen UB. Schoeberl B, et al. Sci Signal. 2009 Jun 30;2(77):ra31. doi: 10.1126/scisignal.2000352. Sci Signal. 2009. PMID: 19567914

6

An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation.

Schoeberl B, Faber AC, Li D, Liang MC, Crosby K, Onsum M, Burenkova O, Pace E, Walton Z, Nie L, Fulgham A, Song Y, Nielsen UB, Engelman JA, Wong KK. Schoeberl B, et al. Cancer Res. 2010 Mar 15;70(6):2485-94. doi: 10.1158/0008-5472.CAN-09-3145. Epub 2010 Mar 9. Cancer Res. 2010. PMID: 20215504 Free PMC article.

7

Optimizing properties of antireceptor antibodies using kinetic computational models and experiments.

Harms BD, Kearns JD, Su SV, Kohli N, Nielsen UB, Schoeberl B. Harms BD, et al. Among authors: schoeberl b. Methods Enzymol. 2012;502:67-87. doi: 10.1016/B978-0-12-416039-2.00004-5. Methods Enzymol. 2012. PMID: 22208982

8

Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.

McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S, Zhang B, Luus L, Overland R, Nguyen S, Gu J, Kohli N, Wallace M, Feldhaus MJ, Kudla AJ, Schoeberl B, Nielsen UB. McDonagh CF, et al. Among authors: schoeberl b. Mol Cancer Ther. 2012 Mar;11(3):582-93. doi: 10.1158/1535-7163.MCT-11-0820. Epub 2012 Jan 16. Mol Cancer Ther. 2012. PMID: 22248472

9

Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies.

Zhou Y, Goenaga AL, Harms BD, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD. Zhou Y, et al. Among authors: schoeberl b. Mol Cancer Ther. 2012 Jul;11(7):1467-76. doi: 10.1158/1535-7163.MCT-11-1038. Epub 2012 May 7. Mol Cancer Ther. 2012. PMID: 22564724 Free PMC article.

10

Rapid optimization and prototyping for therapeutic antibody-like molecules.

Xu L, Kohli N, Rennard R, Jiao Y, Razlog M, Zhang K, Baum J, Johnson B, Tang J, Schoeberl B, Fitzgerald J, Nielsen U, Lugovskoy AA. Xu L, et al. Among authors: schoeberl b. MAbs. 2013 Mar-Apr;5(2):237-54. doi: 10.4161/mabs.23363. Epub 2013 Feb 7. MAbs. 2013. PMID: 23392215 Free PMC article.

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