Darville N - Search Results

1

The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.

Darville N, van Heerden M, Mariën D, De Meulder M, Rossenu S, Vermeulen A, Vynckier A, De Jonghe S, Sterkens P, Annaert P, Van den Mooter G. Darville N, et al. J Control Release. 2016 May 28;230:95-108. doi: 10.1016/j.jconrel.2016.03.041. Epub 2016 Apr 9. J Control Release. 2016. PMID: 27067365

2

Intramuscular administration of paliperidone palmitate extended-release injectable microsuspension induces a subclinical inflammatory reaction modulating the pharmacokinetics in rats.

Darville N, van Heerden M, Vynckier A, De Meulder M, Sterkens P, Annaert P, Van den Mooter G. Darville N, et al. J Pharm Sci. 2014 Jul;103(7):2072-2087. doi: 10.1002/jps.24014. Epub 2014 May 20. J Pharm Sci. 2014. PMID: 24845884

3

Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions.

Darville N, Saarinen J, Isomäki A, Khriachtchev L, Cleeren D, Sterkens P, van Heerden M, Annaert P, Peltonen L, Santos HA, Strachan CJ, Van den Mooter G. Darville N, et al. Eur J Pharm Biopharm. 2015 Oct;96:338-48. doi: 10.1016/j.ejpb.2015.09.003. Epub 2015 Sep 5. Eur J Pharm Biopharm. 2015. PMID: 26347923

4

Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat.

Darville N, van Heerden M, Erkens T, De Jonghe S, Vynckier A, De Meulder M, Vermeulen A, Sterkens P, Annaert P, Van den Mooter G. Darville N, et al. Toxicol Pathol. 2016 Feb;44(2):189-210. doi: 10.1177/0192623315618291. Epub 2015 Dec 23. Toxicol Pathol. 2016. PMID: 26698322

5

Comparison of the Local Tolerability to 5 Long-acting Drug Nanosuspensions with Different Stabilizing Excipients, Following a Single Intramuscular Administration in the Rat.

Chamanza R, Darville N, van Heerden M, De Jonghe S. Chamanza R, et al. Among authors: darville n. Toxicol Pathol. 2018 Jan;46(1):85-100. doi: 10.1177/0192623317737295. Epub 2017 Nov 2. Toxicol Pathol. 2018. PMID: 29096596

6

Linking In Vitro Intrinsic Dissolution Rate and Thermodynamic Solubility with Pharmacokinetic Profiles of Bedaquiline Long-Acting Aqueous Microsuspensions in Rats.

Nguyen V, Bevernage J, Darville N, Tistaert C, Van Bocxlaer J, Rossenu S, Vermeulen A. Nguyen V, et al. Among authors: darville n. Mol Pharm. 2021 Mar 1;18(3):952-965. doi: 10.1021/acs.molpharmaceut.0c00948. Epub 2021 Jan 5. Mol Pharm. 2021. PMID: 33400546

7

Pharmacokinetics of Long-Acting Aqueous Nano-/Microsuspensions After Intramuscular Administration in Different Animal Species and Humans-a Review.

Nguyen VTT, Darville N, Vermeulen A. Nguyen VTT, et al. Among authors: darville n. AAPS J. 2022 Dec 1;25(1):4. doi: 10.1208/s12248-022-00771-5. AAPS J. 2022. PMID: 36456852 Review.

8

Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development.

Siemons M, Schroyen B, Darville N, Goyal N. Siemons M, et al. Among authors: darville n. AAPS J. 2023 Oct 17;25(6):99. doi: 10.1208/s12248-023-00864-9. AAPS J. 2023. PMID: 37848754 Review.

9

The use of supersaturation for the vaginal application of microbicides: a case study with dapivirine.

Grammen C, Plum J, Van Den Brande J, Darville N, Augustyns K, Augustijns P, Brouwers J. Grammen C, et al. Among authors: darville n. J Pharm Sci. 2014 Nov;103(11):3696-3703. doi: 10.1002/jps.24176. Epub 2014 Sep 17. J Pharm Sci. 2014. PMID: 25231545

10

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.

Kesteleyn B, Herschke F, Darville N, Stoops B, Jacobs T, Jacoby E, Shaffer P, Lammens L, Van Rompaey D, Matcha K, Martinez Lamenca C, Coesemans E, Hache G, Pieters S, Lecomte M, Hu L, Demin S, Milligan C, Abeywickrema P, De Bruyn S, Van Den Berg J, Ysebaert N, De Zwart L, Nájera I, Rigaux P, Roymans D, Jonckers THM. Kesteleyn B, et al. Among authors: darville n. J Med Chem. 2024 Jul 11;67(13):10986-11002. doi: 10.1021/acs.jmedchem.4c00514. Epub 2024 Jun 26. J Med Chem. 2024. PMID: 38932487

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