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Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Nguyen TX, et al. Among authors: marchand c. J Med Chem. 2012 May 10;55(9):4457-78. doi: 10.1021/jm300335n. Epub 2012 Apr 26. J Med Chem. 2012. PMID: 22536944 Free PMC article.
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
Conda-Sheridan M, Reddy PV, Morrell A, Cobb BT, Marchand C, Agama K, Chergui A, Renaud A, Stephen AG, Bindu LK, Pommier Y, Cushman M. Conda-Sheridan M, et al. Among authors: marchand c. J Med Chem. 2013 Jan 10;56(1):182-200. doi: 10.1021/jm3014458. Epub 2012 Dec 21. J Med Chem. 2013. PMID: 23259865 Free PMC article.
Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).
Beck DE, Agama K, Marchand C, Chergui A, Pommier Y, Cushman M. Beck DE, et al. Among authors: marchand c. J Med Chem. 2014 Feb 27;57(4):1495-512. doi: 10.1021/jm401814y. Epub 2014 Feb 11. J Med Chem. 2014. PMID: 24517248 Free PMC article.
Interfacial inhibitors.
Pommier Y, Kiselev E, Marchand C. Pommier Y, et al. Among authors: marchand c. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3961-5. doi: 10.1016/j.bmcl.2015.07.032. Epub 2015 Jul 18. Bioorg Med Chem Lett. 2015. PMID: 26235949 Free PMC article. Review.
507 results