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Therapeutic antibody targeting of individual Notch receptors.
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: siebel cw. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Lafkas D, Shelton A, Chiu C, de Leon Boenig G, Chen Y, Stawicki SS, Siltanen C, Reichelt M, Zhou M, Wu X, Eastham-Anderson J, Moore H, Roose-Girma M, Chinn Y, Hang JQ, Warming S, Egen J, Lee WP, Austin C, Wu Y, Payandeh J, Lowe JB, Siebel CW. Lafkas D, et al. Among authors: siebel cw. Nature. 2015 Dec 3;528(7580):127-31. doi: 10.1038/nature15715. Epub 2015 Nov 18. Nature. 2015. PMID: 26580007
Notch signalling drives synovial fibroblast identity and arthritis pathology.
Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT; Accelerating Medicines Partnership Rheumatoid Arthritis & Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB. Wei K, et al. Nature. 2020 Jun;582(7811):259-264. doi: 10.1038/s41586-020-2222-z. Epub 2020 Apr 22. Nature. 2020. PMID: 32499639 Free PMC article.
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.
López-Arribillaga E, Rodilla V, Colomer C, Vert A, Shelton A, Cheng JH, Yan B, Gonzalez-Perez A, Junttila MR, Iglesias M, Torres F, Albanell J, Villanueva A, Bigas A, Siebel CW, Espinosa L. López-Arribillaga E, et al. Among authors: siebel cw. Nat Commun. 2018 Jul 31;9(1):2992. doi: 10.1038/s41467-018-05385-0. Nat Commun. 2018. PMID: 30065304 Free PMC article.
Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms.
Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Magee CN, et al. Circulation. 2019 Sep 9;140(10):846-863. doi: 10.1161/CIRCULATIONAHA.119.040563. Epub 2019 Jul 3. Circulation. 2019. PMID: 31266349 Free PMC article.
83 results