Caldecott KW - Search Results

1

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Among authors: caldecott kw. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.

2

DNA Combing versus DNA Spreading and the Separation of Sister Chromatids.

Meroni A, Wells SE, Fonseca C, Ray Chaudhuri A, Caldecott KW, Vindigni A. Meroni A, et al. Among authors: caldecott kw. bioRxiv [Preprint]. 2023 May 2:2023.05.02.539129. doi: 10.1101/2023.05.02.539129. bioRxiv. 2023. Update in: J Cell Biol. 2024 Apr 1;223(4):e202305082. doi: 10.1083/jcb.202305082 PMID: 37205507 Free PMC article. Updated. Preprint.

3

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW. Cortes Ledesma F, et al. Among authors: caldecott kw. Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444. Nature. 2009. PMID: 19794497

4

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW. Zeng Z, et al. Among authors: caldecott kw. J Biol Chem. 2011 Jan 7;286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28. J Biol Chem. 2011. PMID: 21030584 Free PMC article.

5

APLF promotes the assembly and activity of non-homologous end joining protein complexes.

Grundy GJ, Rulten SL, Zeng Z, Arribas-Bosacoma R, Iles N, Manley K, Oliver A, Caldecott KW. Grundy GJ, et al. Among authors: caldecott kw. EMBO J. 2013 Jan 9;32(1):112-25. doi: 10.1038/emboj.2012.304. Epub 2012 Nov 23. EMBO J. 2013. PMID: 23178593 Free PMC article.

6

Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.

Thomson G, Watson A, Caldecott K, Denneny O, Depledge P, Hamilton N, Hopkins G, Jordan A, Morrow C, Raoof A, Waddell I, Ogilvie D. Thomson G, et al. Anal Biochem. 2013 May 15;436(2):145-50. doi: 10.1016/j.ab.2013.02.001. Epub 2013 Feb 12. Anal Biochem. 2013. PMID: 23416181

7

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.

Breslin C, Hornyak P, Ridley A, Rulten SL, Hanzlikova H, Oliver AW, Caldecott KW. Breslin C, et al. Among authors: caldecott kw. Nucleic Acids Res. 2015 Aug 18;43(14):6934-44. doi: 10.1093/nar/gkv623. Epub 2015 Jun 29. Nucleic Acids Res. 2015. PMID: 26130715 Free PMC article.

8

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.

Grundy GJ, Rulten SL, Arribas-Bosacoma R, Davidson K, Kozik Z, Oliver AW, Pearl LH, Caldecott KW. Grundy GJ, et al. Among authors: caldecott kw. Nat Commun. 2016 Apr 11;7:11242. doi: 10.1038/ncomms11242. Nat Commun. 2016. PMID: 27063109 Free PMC article.

9

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

Grundy GJ, Polo LM, Zeng Z, Rulten SL, Hoch NC, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, Caldecott KW. Grundy GJ, et al. Among authors: caldecott kw. Nat Commun. 2016 Aug 17;7:12404. doi: 10.1038/ncomms12404. Nat Commun. 2016. PMID: 27530147 Free PMC article.

10

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.

Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium; Yoon G, Caldecott KW. Hoch NC, et al. Among authors: caldecott kw. Nature. 2017 Jan 5;541(7635):87-91. doi: 10.1038/nature20790. Epub 2016 Dec 21. Nature. 2017. PMID: 28002403 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

140 results

Search Page

Filters