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Intramuscular primary immunization by nucleic acid vaccine pcDNA/Gpd-IL-2 and enhanced immunization with mucosal adjuvant CpG-ODN and Gpd-IL-2 recombinant protein effectively induced strong mucosal immune responses and immune protective effects against Treponema pallidum skin infection.
Zhang X, Zhao T, Zeng T, Wu N, Xiao Y, Liu S, Yu J, Jiang C, Gan L, Deng M, Luo X, Zhao F. Zhang X, et al. Among authors: yu j. Exp Ther Med. 2018 Mar;15(3):2533-2540. doi: 10.3892/etm.2018.5689. Epub 2018 Jan 4. Exp Ther Med. 2018. PMID: 29456657 Free PMC article.
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