Fyfe MC - Search Results

1

Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis.

Biancheri P, Foster MR, Fyfe MC, MacDonald TT, Sirohi S, Solanke Y, Wood E, Rowley A, Webber S, Walshe CA. Biancheri P, et al. Among authors: fyfe mc. Inflamm Bowel Dis. 2016 Jun;22(6):1306-15. doi: 10.1097/MIB.0000000000000759. Inflamm Bowel Dis. 2016. PMID: 27104822 Free PMC article.

2

Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders.

Hagan S, Fyfe MCT, Ofori-Frimpong B, Oliver K, Foster MR, Sirohi S, Solanke Y, Doughty M, Rowley A, Taylor M, Webber S, Walshe CA. Hagan S, et al. Among authors: fyfe mct. Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1443-1453. doi: 10.1167/iovs.17-23479. Invest Ophthalmol Vis Sci. 2018. PMID: 29625466

3

A phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease.

Taylor M, Ousler G, Torkildsen G, Walshe C, Fyfe MCT, Rowley A, Webber S, Sheppard JD, Duggal A. Taylor M, et al. Among authors: fyfe mct. Clin Ophthalmol. 2019 Feb 12;13:261-275. doi: 10.2147/OPTH.S189039. eCollection 2019. Clin Ophthalmol. 2019. PMID: 30858682 Free PMC article.

4

Non-systemic Intestine-Targeted Drugs.

Fyfe MC. Fyfe MC. Prog Med Chem. 2016;55:1-44. doi: 10.1016/bs.pmch.2015.10.001. Epub 2016 Jan 12. Prog Med Chem. 2016. PMID: 26852933 Review. No abstract available.

5

SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.

Bertram LS, Black D, Briner PH, Chatfield R, Cooke A, Fyfe MC, Murray PJ, Naud F, Nawano M, Procter MJ, Rakipovski G, Rasamison CM, Reynet C, Schofield KL, Shah VK, Spindler F, Taylor A, Turton R, Williams GM, Wong-Kai-In P, Yasuda K. Bertram LS, et al. Among authors: fyfe mc. J Med Chem. 2008 Jul 24;51(14):4340-5. doi: 10.1021/jm8003202. Epub 2008 Jun 28. J Med Chem. 2008. PMID: 18588279

6

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.

Fyfe MC, White JR, Taylor A, Chatfield R, Wargent E, Printz RL, Sulpice T, McCormack JG, Procter MJ, Reynet C, Widdowson PS, Wong-Kai-In P. Fyfe MC, et al. Diabetologia. 2007 Jun;50(6):1277-87. doi: 10.1007/s00125-007-0646-8. Epub 2007 Apr 6. Diabetologia. 2007. PMID: 17415548

7

Glucokinase-activating ureas.

Castelhano AL, Dong H, Fyfe MC, Gardner LS, Kamikozawa Y, Kurabayashi S, Nawano M, Ohashi R, Procter MJ, Qiu L, Rasamison CM, Schofield KL, Shah VK, Ueta K, Williams GM, Witter D, Yasuda K. Castelhano AL, et al. Among authors: fyfe mc. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1501-4. doi: 10.1016/j.bmcl.2004.12.083. Bioorg Med Chem Lett. 2005. PMID: 15713416

8

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.

Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C. Overton HA, et al. Among authors: fyfe mc. Cell Metab. 2006 Mar;3(3):167-75. doi: 10.1016/j.cmet.2006.02.004. Cell Metab. 2006. PMID: 16517404 Free article.

9

GPR119 agonists as potential new oral agents for the treatment of type 2 diabetes and obesity.

Fyfe MC, McCormack JG, Overton HA, Procter MJ, Reynet C. Fyfe MC, et al. Expert Opin Drug Discov. 2008 Apr;3(4):403-13. doi: 10.1517/17460441.3.4.403. Expert Opin Drug Discov. 2008. PMID: 23489096

10

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity.

Overton HA, Fyfe MC, Reynet C. Overton HA, et al. Among authors: fyfe mc. Br J Pharmacol. 2008 Mar;153 Suppl 1(Suppl 1):S76-81. doi: 10.1038/sj.bjp.0707529. Epub 2007 Nov 26. Br J Pharmacol. 2008. PMID: 18037923 Free PMC article. Review.

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