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Page 1
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.
Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B. Dourlen P, et al. Among authors: obriot h. Mol Psychiatry. 2017 Jun;22(6):874-883. doi: 10.1038/mp.2016.59. Epub 2016 Apr 26. Mol Psychiatry. 2017. PMID: 27113998 Free PMC article.
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Belarbi K, Burnouf S, Fernandez-Gomez FJ, Laurent C, Lestavel S, Figeac M, Sultan A, Troquier L, Leboucher A, Caillierez R, Grosjean ME, Demeyer D, Obriot H, Brion I, Barbot B, Galas MC, Staels B, Humez S, Sergeant N, Schraen-Maschke S, Muhr-Tailleux A, Hamdane M, Buée L, Blum D. Belarbi K, et al. Among authors: obriot h. Neurobiol Dis. 2011 Aug;43(2):486-94. doi: 10.1016/j.nbd.2011.04.022. Epub 2011 May 4. Neurobiol Dis. 2011. PMID: 21569847
Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation.
Papegaey A, Eddarkaoui S, Deramecourt V, Fernandez-Gomez FJ, Pantano P, Obriot H, Machala C, Anquetil V, Camuzat A, Brice A, Maurage CA, Le Ber I, Duyckaerts C, Buée L, Sergeant N, Buée-Scherrer V. Papegaey A, et al. Among authors: obriot h. Acta Neuropathol Commun. 2016 Jul 19;4(1):74. doi: 10.1186/s40478-016-0345-0. Acta Neuropathol Commun. 2016. PMID: 27435172 Free PMC article.
From tau phosphorylation to tau aggregation: what about neuronal death?
Buée L, Troquier L, Burnouf S, Belarbi K, Van der Jeugd A, Ahmed T, Fernandez-Gomez F, Caillierez R, Grosjean ME, Begard S, Barbot B, Demeyer D, Obriot H, Brion I, Buée-Scherrer V, Maurage CA, Balschun D, D'hooge R, Hamdane M, Blum D, Sergeant N. Buée L, et al. Among authors: obriot h. Biochem Soc Trans. 2010 Aug;38(4):967-72. doi: 10.1042/BST0380967. Biochem Soc Trans. 2010. PMID: 20658986 Review.
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF. Blum D, et al. Among authors: obriot h. Hum Mol Genet. 2015 Jan 1;24(1):76-85. doi: 10.1093/hmg/ddu421. Epub 2014 Aug 20. Hum Mol Genet. 2015. PMID: 25143394
[Biological markers in Alzheimer disease: what are the chances for less slow diagnosis?].
Schraen-Maschke S, Dhaenens CM, Bombois S, Deramecourt V, Van Brussel E, Obriot H, Marzys C, Sergeant N, Maurage CA, Pasquier F, Sablonnière B, Buée L. Schraen-Maschke S, et al. Among authors: obriot h. Rev Neurol (Paris). 2009 Apr;165 Spec No 2:F97-103. Rev Neurol (Paris). 2009. PMID: 19593884 Review. French. No abstract available.
Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing.
Dhaenens CM, Tran H, Frandemiche ML, Carpentier C, Schraen-Maschke S, Sistiaga A, Goicoechea M, Eddarkaoui S, Van Brussels E, Obriot H, Labudeck A, Gevaert MH, Fernandez-Gomez F, Charlet-Berguerand N, Deramecourt V, Maurage CA, Buée L, Lopez de Munain A, Sablonnière B, Caillet-Boudin ML, Sergeant N. Dhaenens CM, et al. Among authors: obriot h. Biochim Biophys Acta. 2011 Jul;1812(7):732-42. doi: 10.1016/j.bbadis.2011.03.010. Epub 2011 Mar 23. Biochim Biophys Acta. 2011. PMID: 21439371 Free article.
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P. Sergeant N, et al. Among authors: obriot h. Neurobiol Dis. 2019 Sep;129:217-233. doi: 10.1016/j.nbd.2019.03.028. Epub 2019 Mar 27. Neurobiol Dis. 2019. PMID: 30928644
Consensus brain-derived protein, extraction protocol for the study of human and murine brain proteome using both 2D-DIGE and mini 2DE immunoblotting.
Fernandez-Gomez FJ, Jumeau F, Derisbourg M, Burnouf S, Tran H, Eddarkaoui S, Obriot H, Dutoit-Lefevre V, Deramecourt V, Mitchell V, Lefranc D, Hamdane M, Blum D, Buée L, Buée-Scherrer V, Sergeant N. Fernandez-Gomez FJ, et al. Among authors: obriot h. J Vis Exp. 2014 Apr 10;(86):51339. doi: 10.3791/51339. J Vis Exp. 2014. PMID: 24747743 Free PMC article.
17 results