Yang HK - Search Results

1

Design, synthesis and antiproliferative activity of novel 5-nitropyrimidine-2,4-diamine derivatives bearing alkyl acetate moiety.

Zhao PL, Li YH, Yang HK, Chen P, Zhang B, Sun Q, Li Q, You WW. Zhao PL, et al. Among authors: yang hk. Eur J Med Chem. 2016 Aug 8;118:161-9. doi: 10.1016/j.ejmech.2016.04.038. Epub 2016 Apr 16. Eur J Med Chem. 2016. PMID: 27128180

2

Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety.

Zhao PL, Duan AN, Zou M, Yang HK, You WW, Wu SG. Zhao PL, et al. Among authors: yang hk. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4471-4. doi: 10.1016/j.bmcl.2012.03.023. Epub 2012 Mar 11. Bioorg Med Chem Lett. 2012. PMID: 22647723

3

One-pot synthesis and antiproliferative activity of novel 2,4-diaminopyrimidine derivatives bearing piperidine and piperazine moieties.

Ma WF, Yang HK, Hu MJ, Li Q, Ma TZ, Zhou ZZ, Liu RY, You WW, Zhao PL. Ma WF, et al. Among authors: yang hk. Eur J Med Chem. 2014 Sep 12;84:127-34. doi: 10.1016/j.ejmech.2014.07.017. Epub 2014 Jul 7. Eur J Med Chem. 2014. PMID: 25016234

4

Design, Synthesis and Molecular Docking Studies of Novel Indole-Pyrimidine Hybrids as Tubulin Polymerization Inhibitors.

Hu MJ, Zhang B, Yang HK, Liu Y, Chen YR, Ma TZ, Lu L, You WW, Zhao PL. Hu MJ, et al. Among authors: yang hk. Chem Biol Drug Des. 2015 Dec;86(6):1491-500. doi: 10.1111/cbdd.12616. Epub 2015 Aug 3. Chem Biol Drug Des. 2015. PMID: 26177395

5

Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues.

Li YH, Zhang B, Yang HK, Li Q, Diao PC, You WW, Zhao PL. Li YH, et al. Among authors: yang hk. Eur J Med Chem. 2017 Jan 5;125:1098-1106. doi: 10.1016/j.ejmech.2016.10.051. Epub 2016 Oct 24. Eur J Med Chem. 2017. PMID: 27810596

6

Design, synthesis and antiproliferative activity of novel substituted 2-amino-7,8-dihydropteridin-6(5H)-one derivatives.

Li Q, Yang HK, Sun Q, You WW, Zhao PL. Li Q, et al. Among authors: yang hk. Bioorg Med Chem Lett. 2017 Sep 1;27(17):3954-3958. doi: 10.1016/j.bmcl.2017.07.076. Epub 2017 Jul 29. Bioorg Med Chem Lett. 2017. PMID: 28789892

7

Facile one-pot synthesis, antiproliferative evaluation and structure-activity relationships of 3-amino-1H-indoles and 3-amino-1H-7-azaindoles.

Diao PC, Hu MJ, Yang HK, You WW, Zhao PL. Diao PC, et al. Among authors: yang hk. Bioorg Chem. 2019 Jul;88:102914. doi: 10.1016/j.bioorg.2019.04.008. Epub 2019 Apr 10. Bioorg Chem. 2019. PMID: 30991193

8

3-{2-[(1,3-Benzothia-zol-2-yl)sulfanyl-meth-yl]phen-yl}-4-meth-oxy-5,5-dimethyl-furan-2(5H)-one.

Duan A, Yang H, Zhao P, You W. Duan A, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1854. doi: 10.1107/S1600536812022404. Epub 2012 May 23. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22719619 Free PMC article.

9

Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.

Yang H, Yan R, Jiang Y, Yang Z, Zhang X, Zhou M, Wu X, Zhang T, Zhang J. Yang H, et al. Eur J Med Chem. 2020 Feb 1;187:111966. doi: 10.1016/j.ejmech.2019.111966. Epub 2019 Dec 14. Eur J Med Chem. 2020. PMID: 31869655 Review.

10

Evolution strategy of ROS1 kinase inhibitors for use in cancer therapy.

Liu S, Yang H, Jiang Y, Zhang T, Yan R, Zhang J. Liu S, et al. Future Med Chem. 2018 Jul 1;10(14):1705-1720. doi: 10.4155/fmc-2018-0033. Epub 2018 Jul 2. Future Med Chem. 2018. PMID: 29961337 Review.

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