Wang L - Search Results

1

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

Zhang Z, Hou S, Chen H, Ran T, Jiang F, Bian Y, Zhang D, Zhi Y, Wang L, Zhang L, Li H, Zhang Y, Tang W, Lu T, Chen Y. Zhang Z, et al. Among authors: wang l. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2931-2935. doi: 10.1016/j.bmcl.2016.04.034. Epub 2016 Apr 22. Bioorg Med Chem Lett. 2016. PMID: 27142751

2

Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.

Zhang L, Zhang B, Zhao J, Zhi Y, Wang L, Lu T, Chen Y. Zhang L, et al. Among authors: wang l. Eur J Med Chem. 2017 Sep 29;138:942-951. doi: 10.1016/j.ejmech.2017.06.057. Epub 2017 Jun 29. Eur J Med Chem. 2017. PMID: 28755635

3

Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines.

Zhang Y, Chen Y, Zhang D, Wang L, Lu T, Jiao Y. Zhang Y, et al. Among authors: wang l. J Med Chem. 2018 Jan 11;61(1):140-157. doi: 10.1021/acs.jmedchem.7b01091. Epub 2017 Dec 19. J Med Chem. 2018. PMID: 29189002

4

Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.

Wang L, Zhang Y, Zhang Q, Zhu G, Zhang Z, Duan C, Lu T, Tang W. Wang L, et al. Eur J Med Chem. 2019 Feb 1;163:243-255. doi: 10.1016/j.ejmech.2018.11.033. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30529543

5

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

Wang L, Zhang Q, Zhu G, Zhang Z, Zhi Y, Zhang L, Mao T, Zhou X, Chen Y, Lu T, Tang W. Wang L, et al. Eur J Med Chem. 2017 Apr 21;130:86-106. doi: 10.1016/j.ejmech.2017.02.041. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28242553

6

Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.

Wang L, Zhu G, Zhang Q, Duan C, Zhang Y, Zhang Z, Zhou Y, Lu T, Tang W. Wang L, et al. Org Biomol Chem. 2017 Apr 18;15(16):3455-3465. doi: 10.1039/c7ob00518k. Org Biomol Chem. 2017. PMID: 28368067

7

Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance.

Zhang Y, Wang L, Zhang Q, Zhu G, Zhang Z, Zhou X, Chen Y, Lu T, Tang W. Zhang Y, et al. Among authors: wang l. J Chem Inf Model. 2017 Jun 26;57(6):1439-1452. doi: 10.1021/acs.jcim.6b00795. Epub 2017 May 19. J Chem Inf Model. 2017. PMID: 28485964

8

Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition.

Xu S, Fan R, Wang L, He W, Ge H, Chen H, Xu W, Zhang J, Xu W, Feng Y, Fan Z. Xu S, et al. Among authors: wang l. J Enzyme Inhib Med Chem. 2022 Dec;37(1):236-251. doi: 10.1080/14756366.2021.2001805. J Enzyme Inhib Med Chem. 2022. PMID: 34894961 Free PMC article.

9

Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.

Wang Y, Ai J, Wang Y, Chen Y, Wang L, Liu G, Geng M, Zhang A. Wang Y, et al. Among authors: wang l. J Med Chem. 2011 Apr 14;54(7):2127-42. doi: 10.1021/jm101340q. Epub 2011 Mar 15. J Med Chem. 2011. PMID: 21405128

10

Divergent de novo synthesis of 2,4,5-trideoxyhexopyranosides derivatives of podophyllotoxin as anticancer agents.

Lu Y, Wang L, Wang X, Yuan H, Zhao Y. Lu Y, et al. Among authors: wang x, wang l. Future Med Chem. 2019 Dec;11(23):3015-3027. doi: 10.4155/fmc-2018-0593. Epub 2019 Oct 31. Future Med Chem. 2019. PMID: 31668097

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