Wheadon H - Search Results

1

Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia.

Irvine DA, Zhang B, Kinstrie R, Tarafdar A, Morrison H, Campbell VL, Moka HA, Ho Y, Nixon C, Manley PW, Wheadon H, Goodlad JR, Holyoake TL, Bhatia R, Copland M. Irvine DA, et al. Among authors: wheadon h. Sci Rep. 2016 May 9;6:25476. doi: 10.1038/srep25476. Sci Rep. 2016. PMID: 27157927 Free PMC article.

2

Targeting self-renewal pathways in myeloid malignancies.

Sands WA, Copland M, Wheadon H. Sands WA, et al. Among authors: wheadon h. Cell Commun Signal. 2013 May 15;11(1):33. doi: 10.1186/1478-811X-11-33. Cell Commun Signal. 2013. PMID: 23675967 Free PMC article.

3

Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation.

Tarafdar A, Dobbin E, Corrigan P, Freeburn R, Wheadon H. Tarafdar A, et al. Among authors: wheadon h. PLoS One. 2013 Nov 26;8(11):e81030. doi: 10.1371/journal.pone.0081030. eCollection 2013. PLoS One. 2013. PMID: 24324557 Free PMC article.

4

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.

Gallipoli P, Cook A, Rhodes S, Hopcroft L, Wheadon H, Whetton AD, Jørgensen HG, Bhatia R, Holyoake TL. Gallipoli P, et al. Among authors: wheadon h. Blood. 2014 Aug 28;124(9):1492-501. doi: 10.1182/blood-2013-12-545640. Epub 2014 Jun 23. Blood. 2014. PMID: 24957147 Free PMC article.

5

The role of the bone morphogenetic proteins in leukaemic stem cell persistence.

Toofan P, Irvine D, Hopcroft L, Copland M, Wheadon H. Toofan P, et al. Among authors: wheadon h. Biochem Soc Trans. 2014 Aug;42(4):809-15. doi: 10.1042/BST20140037. Biochem Soc Trans. 2014. PMID: 25109962 Review.

6

Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma.

Ford CA, Petrova S, Pound JD, Voss JJ, Melville L, Paterson M, Farnworth SL, Gallimore AM, Cuff S, Wheadon H, Dobbin E, Ogden CA, Dumitriu IE, Dunbar DR, Murray PG, Ruckerl D, Allen JE, Hume DA, van Rooijen N, Goodlad JR, Freeman TC, Gregory CD. Ford CA, et al. Among authors: wheadon h. Curr Biol. 2015 Mar 2;25(5):577-88. doi: 10.1016/j.cub.2014.12.059. Epub 2015 Feb 19. Curr Biol. 2015. PMID: 25702581 Free PMC article.

7

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis.

Toofan P, Wheadon H. Toofan P, et al. Among authors: wheadon h. Biochem Soc Trans. 2016 Oct 15;44(5):1455-1463. doi: 10.1042/BST20160104. Biochem Soc Trans. 2016. PMID: 27911727 Free article. Review.

8

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.

Toofan P, Busch C, Morrison H, O'Brien S, Jørgensen H, Copland M, Wheadon H. Toofan P, et al. Among authors: wheadon h. Cell Death Dis. 2018 Sep 11;9(9):927. doi: 10.1038/s41419-018-0905-2. Cell Death Dis. 2018. PMID: 30206237 Free PMC article.

9

Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML.

Busch C, Wheadon H. Busch C, et al. Among authors: wheadon h. Biochem Soc Trans. 2019 Oct 31;47(5):1307-1325. doi: 10.1042/BST20190221. Biochem Soc Trans. 2019. PMID: 31551354 Free article.

10

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.

Kinstrie R, Horne GA, Morrison H, Irvine D, Munje C, Castañeda EG, Moka HA, Dunn K, Cassels JE, Parry N, Clarke CJ, Scott MT, Clark RE, Holyoake TL, Wheadon H, Copland M. Kinstrie R, et al. Among authors: wheadon h. Leukemia. 2020 Jun;34(6):1613-1625. doi: 10.1038/s41375-019-0684-5. Epub 2020 Jan 2. Leukemia. 2020. PMID: 31896780 Free PMC article.

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