Carvalho RA - Search Results

1

Exploring new chemical functionalities to improve aromatase inhibition of steroids.

Varela CL, Amaral C, Correia-da-Silva G, Costa SC, Carvalho RA, Costa G, Alcaro S, Teixeira NA, Tavares-da-Silva EJ, Roleira FM. Varela CL, et al. Among authors: carvalho ra. Bioorg Med Chem. 2016 Jun 15;24(12):2823-31. doi: 10.1016/j.bmc.2016.04.056. Epub 2016 Apr 26. Bioorg Med Chem. 2016. PMID: 27160054

2

Lipophilic phenolic antioxidants: correlation between antioxidant profile, partition coefficients and redox properties.

Roleira FM, Siquet C, Orrù E, Garrido EM, Garrido J, Milhazes N, Podda G, Paiva-Martins F, Reis S, Carvalho RA, Silva EJ, Borges F. Roleira FM, et al. Among authors: carvalho ra. Bioorg Med Chem. 2010 Aug 15;18(16):5816-25. doi: 10.1016/j.bmc.2010.06.090. Epub 2010 Jul 1. Bioorg Med Chem. 2010. PMID: 20650639

3

New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation.

Varela C, Tavares da Silva EJ, Amaral C, Correia da Silva G, Baptista T, Alcaro S, Costa G, Carvalho RA, Teixeira NA, Roleira FM. Varela C, et al. Among authors: carvalho ra. J Med Chem. 2012 Apr 26;55(8):3992-4002. doi: 10.1021/jm300262w. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22475216

4

Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors.

Varela CL, Amaral C, Correia-da-Silva G, Carvalho RA, Teixeira NA, Costa SC, Roleira FM, Tavares-da-Silva EJ. Varela CL, et al. Among authors: carvalho ra. Steroids. 2013 Jul;78(7):662-9. doi: 10.1016/j.steroids.2013.02.016. Epub 2013 Mar 13. Steroids. 2013. PMID: 23499824

5

New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line.

Amaral C, Varela C, Correia-da-Silva G, Tavares da Silva E, Carvalho RA, Costa SC, Cunha SC, Fernandes JO, Teixeira N, Roleira FM. Amaral C, et al. Among authors: carvalho ra. Biochimie. 2013 Nov;95(11):2097-106. doi: 10.1016/j.biochi.2013.07.023. Epub 2013 Aug 9. Biochimie. 2013. PMID: 23933094

6

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.

Varela CL, Amaral C, Tavares da Silva E, Lopes A, Correia-da-Silva G, Carvalho RA, Costa SC, Roleira FM, Teixeira N. Varela CL, et al. Among authors: carvalho ra. Eur J Med Chem. 2014 Nov 24;87:336-45. doi: 10.1016/j.ejmech.2014.09.074. Epub 2014 Sep 28. Eur J Med Chem. 2014. PMID: 25277066

7

Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives.

Tavares-da-Silva EJ, Varela CL, Pires AS, Encarnação JC, Abrantes AM, Botelho MF, Carvalho RA, Proença C, Freitas M, Fernandes E, Roleira FM. Tavares-da-Silva EJ, et al. Among authors: carvalho ra. Bioorg Med Chem. 2016 Aug 15;24(16):3556-64. doi: 10.1016/j.bmc.2016.05.065. Epub 2016 May 30. Bioorg Med Chem. 2016. PMID: 27290693

8

miR-145-loaded micelleplexes as a novel therapeutic strategy to inhibit proliferation and migration of osteosarcoma cells.

Magalhães M, Almeida M, Tavares-da-Silva E, Roleira FMF, Varela C, Jorge J, Gonçalves AC, Carvalho RA, Veiga F, Santos AC, Figueiras A. Magalhães M, et al. Among authors: carvalho ra. Eur J Pharm Sci. 2018 Oct 15;123:28-42. doi: 10.1016/j.ejps.2018.07.021. Epub 2018 Jul 18. Eur J Pharm Sci. 2018. PMID: 30010029

9

Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy.

Carvalho FS, Burgeiro A, Garcia R, Moreno AJ, Carvalho RA, Oliveira PJ. Carvalho FS, et al. Among authors: carvalho ra. Med Res Rev. 2014 Jan;34(1):106-35. doi: 10.1002/med.21280. Epub 2013 Mar 11. Med Res Rev. 2014. PMID: 23494977 Review.

10

One-pot, high yield synthesis of alpha-ketols from Delta5-steroids.

Salvador JA, Moreira VM, Hanson JR, Carvalho RA. Salvador JA, et al. Among authors: carvalho ra. Steroids. 2006 Mar;71(3):266-72. doi: 10.1016/j.steroids.2005.11.002. Epub 2005 Dec 20. Steroids. 2006. PMID: 16368121

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