Huang W - Search Results

1

Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development.

Li Z, Qiu Q, Geng X, Yang J, Huang W, Qian H. Li Z, et al. Among authors: huang w. Expert Opin Investig Drugs. 2016 Aug;25(8):871-90. doi: 10.1080/13543784.2016.1189530. Epub 2016 May 27. Expert Opin Investig Drugs. 2016. PMID: 27171154 Review.

2

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Wang X, Zhao T, Yang B, Li Z, Cui J, Dai Y, Qiu Q, Qiang H, Huang W, Qian H. Wang X, et al. Among authors: huang w. Bioorg Med Chem. 2015 Jan 1;23(1):132-40. doi: 10.1016/j.bmc.2014.11.016. Epub 2014 Nov 20. Bioorg Med Chem. 2015. PMID: 25481394

3

Design, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Li Z, Wang X, Xu X, Yang J, Qiu Q, Qiang H, Huang W, Qian H. Li Z, et al. Among authors: huang w. Bioorg Med Chem. 2015 Oct 15;23(20):6666-72. doi: 10.1016/j.bmc.2015.09.010. Epub 2015 Sep 5. Bioorg Med Chem. 2015. PMID: 26420383

4

Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Li Z, Wang X, Xu X, Yang J, Xia W, Zhou X, Huang W, Qian H. Li Z, et al. Among authors: huang w. Bioorg Med Chem. 2015 Nov 15;23(22):7158-64. doi: 10.1016/j.bmc.2015.10.011. Epub 2015 Oct 8. Bioorg Med Chem. 2015. PMID: 26482570

5

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Li Z, Qiu Q, Xu X, Wang X, Jiao L, Su X, Pan M, Huang W, Qian H. Li Z, et al. Among authors: huang w. Eur J Med Chem. 2016 May 4;113:246-57. doi: 10.1016/j.ejmech.2016.02.040. Epub 2016 Feb 21. Eur J Med Chem. 2016. PMID: 26945112

6

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Li Z, Pan M, Su X, Dai Y, Fu M, Cai X, Shi W, Huang W, Qian H. Li Z, et al. Among authors: huang w. Bioorg Med Chem. 2016 May 1;24(9):1981-7. doi: 10.1016/j.bmc.2016.03.014. Epub 2016 Mar 7. Bioorg Med Chem. 2016. PMID: 27020683

7

Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry.

Li Z, Yang J, Wang X, Li H, Liu C, Wang N, Huang W, Qian H. Li Z, et al. Among authors: huang w. Bioorg Med Chem. 2016 Nov 1;24(21):5449-5454. doi: 10.1016/j.bmc.2016.08.068. Epub 2016 Sep 1. Bioorg Med Chem. 2016. PMID: 27624524

8

Design, synthesis and structure-activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker.

Yang J, Li Z, Li H, Liu C, Wang N, Shi W, Liao C, Cai X, Huang W, Qian H. Yang J, et al. Among authors: huang w. Bioorg Med Chem. 2017 Apr 15;25(8):2445-2450. doi: 10.1016/j.bmc.2017.03.001. Epub 2017 Mar 2. Bioorg Med Chem. 2017. PMID: 28285923

9

Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.

Li Z, Xu X, Huang W, Qian H. Li Z, et al. Among authors: huang w. Med Res Rev. 2018 Mar;38(2):381-425. doi: 10.1002/med.21441. Epub 2017 Mar 22. Med Res Rev. 2018. PMID: 28328012 Review.

10

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Li Z, Liu C, Xu X, Qiu Q, Su X, Dai Y, Yang J, Li H, Shi W, Liao C, Pan M, Huang W, Qian H. Li Z, et al. Among authors: huang w. Eur J Med Chem. 2017 Sep 29;138:458-479. doi: 10.1016/j.ejmech.2017.07.001. Epub 2017 Jul 3. Eur J Med Chem. 2017. PMID: 28689096

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