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Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors.
Dupéré-Richer D, Kinal M, Pettersson F, Emond A, Calvo-Vidal MN, Nichol JN, Guilbert C, Plourde D, Klein Oros K, Nielsen TH, Ezponda T, Licht JD, Johnson NA, Assouline S, Cerchietti L, Miller WH Jr, Mann KK. Dupéré-Richer D, et al. Among authors: licht jd. Leuk Lymphoma. 2017 Jan;58(1):218-221. doi: 10.1080/10428194.2016.1180684. Epub 2016 May 17. Leuk Lymphoma. 2017. PMID: 27185211 No abstract available.
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, Ott HM, Van Aller GS, Kruger RG, Liu Y, McHugh CF, Scott DW, Chung YR, Kelleher N, Shaknovich R, Creasy CL, Gascoyne RD, Wong KK, Cerchietti L, Levine RL, Abdel-Wahab O, Licht JD, Elemento O, Melnick AM. Béguelin W, et al. Among authors: licht jd. Cancer Cell. 2013 May 13;23(5):677-92. doi: 10.1016/j.ccr.2013.04.011. Cancer Cell. 2013. PMID: 23680150 Free PMC article.
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies.
Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD Jr, Kelleher NL, Licht JD, Popovic R. Oyer JA, et al. Among authors: licht jd. Leukemia. 2014 Jan;28(1):198-201. doi: 10.1038/leu.2013.204. Epub 2013 Jul 4. Leukemia. 2014. PMID: 23823660 Free PMC article. No abstract available.
235 results