Wetzel R - Search Results

1

Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR, Nance M, Ross CA, Scahill RI, Wetzel R, Wild EJ, Tabrizi SJ. Bates GP, et al. Among authors: wetzel r. Nat Rev Dis Primers. 2015 Apr 23;1:15005. doi: 10.1038/nrdp.2015.5. Nat Rev Dis Primers. 2015. PMID: 27188817 Review.

2

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.

Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, Pearson J, Vaid K, Bissada N, Wetzel R, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: wetzel r. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11402-7. doi: 10.1073/pnas.0503634102. Epub 2005 Aug 2. Proc Natl Acad Sci U S A. 2005. PMID: 16076956 Free PMC article.

3

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.

Zhou Y, Peskett TR, Landles C, Warner JB, Sathasivam K, Smith EJ, Chen S, Wetzel R, Lashuel HA, Bates GP, Saibil HR. Zhou Y, et al. Among authors: wetzel r. Acta Neuropathol Commun. 2021 Apr 14;9(1):70. doi: 10.1186/s40478-021-01172-z. Acta Neuropathol Commun. 2021. PMID: 33853668 Free PMC article.

4

Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease.

Drombosky KW, Rode S, Kodali R, Jacob TC, Palladino MJ, Wetzel R. Drombosky KW, et al. Among authors: wetzel r. Neurobiol Dis. 2018 Dec;120:126-138. doi: 10.1016/j.nbd.2018.08.019. Epub 2018 Aug 30. Neurobiol Dis. 2018. PMID: 30171891 Free PMC article.

5

Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease.

Wetzel R. Wetzel R. Acc Chem Res. 2020 Oct 20;53(10):2347-2357. doi: 10.1021/acs.accounts.0c00450. Epub 2020 Sep 25. Acc Chem Res. 2020. PMID: 32975927

6

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA. Lin HK, et al. Among authors: wetzel r. Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462. Nat Commun. 2017. PMID: 28537272 Free PMC article.

7

Aggregation behavior of chemically synthesized, full-length huntingtin exon1.

Sahoo B, Singer D, Kodali R, Zuchner T, Wetzel R. Sahoo B, et al. Among authors: wetzel r. Biochemistry. 2014 Jun 24;53(24):3897-907. doi: 10.1021/bi500300c. Epub 2014 Jun 12. Biochemistry. 2014. PMID: 24921664 Free PMC article.

8

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IJ, Anjum DH, Kodali R, Creamer TP, Conway JF, Gronenborn AM, Wetzel R. Thakur AK, et al. Among authors: wetzel r. Nat Struct Mol Biol. 2009 Apr;16(4):380-9. doi: 10.1038/nsmb.1570. Epub 2009 Mar 8. Nat Struct Mol Biol. 2009. PMID: 19270701 Free PMC article.

9

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

Jayaraman M, Kodali R, Sahoo B, Thakur AK, Mayasundari A, Mishra R, Peterson CB, Wetzel R. Jayaraman M, et al. Among authors: wetzel r. J Mol Biol. 2012 Feb 3;415(5):881-99. doi: 10.1016/j.jmb.2011.12.010. Epub 2011 Dec 9. J Mol Biol. 2012. PMID: 22178474 Free PMC article.

10

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.

Jayaraman M, Mishra R, Kodali R, Thakur AK, Koharudin LM, Gronenborn AM, Wetzel R. Jayaraman M, et al. Among authors: wetzel r. Biochemistry. 2012 Apr 3;51(13):2706-16. doi: 10.1021/bi3000929. Epub 2012 Mar 20. Biochemistry. 2012. PMID: 22432740 Free PMC article.

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