Zhu Z - Search Results

1

Synthesis and decreasing Aβ content evaluation of arctigenin-4-yl carbamate derivatives.

Xu X, Li C, Lei M, Zhu Z, Yan J, Shen X, Hu L. Xu X, et al. Among authors: zhu z. Bioorg Med Chem Lett. 2016 Jul 1;26(13):2988-2991. doi: 10.1016/j.bmcl.2016.05.028. Epub 2016 May 10. Bioorg Med Chem Lett. 2016. PMID: 27212069

2

2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.

Zhu Z, Li C, Wang X, Yang Z, Chen J, Hu L, Jiang H, Shen X. Zhu Z, et al. J Neurochem. 2010 Jul;114(2):374-85. doi: 10.1111/j.1471-4159.2010.06751.x. Epub 2010 Apr 19. J Neurochem. 2010. PMID: 20412384 Free article.

3

Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1).

Ma L, Yang Z, Li C, Zhu Z, Shen X, Hu L. Ma L, et al. Among authors: zhu z. J Enzyme Inhib Med Chem. 2011 Oct;26(5):643-8. doi: 10.3109/14756366.2010.543420. Epub 2011 Jan 11. J Enzyme Inhib Med Chem. 2011. PMID: 21222511 Free article.

4

L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells.

Lu Q, Chen WY, Zhu ZY, Chen J, Xu YC, Kaewpet M, Rukachaisirikul V, Chen LL, Shen X. Lu Q, et al. Acta Pharmacol Sin. 2012 Dec;33(12):1459-68. doi: 10.1038/aps.2012.74. Epub 2012 Jul 30. Acta Pharmacol Sin. 2012. PMID: 22842730 Free PMC article.

5

Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability.

Zhou R, Yao X, Xu X, Wang G, Zhu Z, Chen J, Chen L, Shen X. Zhou R, et al. Among authors: zhu z. Steroids. 2013 Oct;78(10):987-95. doi: 10.1016/j.steroids.2013.06.005. Epub 2013 Jul 1. Steroids. 2013. PMID: 23827354

6

Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.

Zhu Z, Yan J, Jiang W, Yao XG, Chen J, Chen L, Li C, Hu L, Jiang H, Shen X. Zhu Z, et al. J Neurosci. 2013 Aug 7;33(32):13138-49. doi: 10.1523/JNEUROSCI.4790-12.2013. J Neurosci. 2013. PMID: 23926267 Free PMC article.

7

Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice.

Wang G, Xu X, Yao X, Zhu Z, Yu L, Chen L, Chen J, Shen X. Wang G, et al. Among authors: zhu z. Diabetologia. 2013 Dec;56(12):2702-12. doi: 10.1007/s00125-013-3032-8. Epub 2013 Aug 29. Diabetologia. 2013. PMID: 23989723

8

Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways.

Wu RM, Sun YY, Zhou TT, Zhu ZY, Zhuang JJ, Tang X, Chen J, Hu LH, Shen X. Wu RM, et al. Acta Pharmacol Sin. 2014 Oct;35(10):1274-84. doi: 10.1038/aps.2014.70. Epub 2014 Aug 25. Acta Pharmacol Sin. 2014. PMID: 25152028 Free PMC article.

9

Aβ regulation-based multitarget strategy for drug discovery against Alzheimer's disease.

Guo X, Jiang W, Li C, Zhu Z, Shen X. Guo X, et al. Among authors: zhu z. Rev Neurosci. 2015;26(1):13-30. doi: 10.1515/revneuro-2014-0064. Rev Neurosci. 2015. PMID: 25720054

10

Small molecule TBTC as a new selective retinoid X receptor α agonist improves behavioral deficit in Alzheimer's disease model mice.

Sun Y, Fan J, Zhu Z, Guo X, Zhou T, Duan W, Shen X. Sun Y, et al. Among authors: zhu z. Eur J Pharmacol. 2015 Sep 5;762:202-13. doi: 10.1016/j.ejphar.2015.05.050. Epub 2015 May 27. Eur J Pharmacol. 2015. PMID: 26026644

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