An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays.
Manservisi F, Marquillas CB, Buscaroli A, Huff J, Lauriola M, Mandrioli D, Manservigi M, Panzacchi S, Silbergeld EK, Belpoggi F.
Manservisi F, et al.
Environ Health Perspect. 2017 Mar;125(3):289-295. doi: 10.1289/EHP419. Epub 2016 Jul 22.
Environ Health Perspect. 2017.
PMID: 27448388
Free PMC article.
CONCLUSION: This integrated study design is efficient in that the same generational cohort of rats used for evaluating long-term outcomes can be monitored in satellite parallel experiments to measure biomarkers and other parameters related to system-specific responses including m …
CONCLUSION: This integrated study design is efficient in that the same generational cohort of rats used for evaluating long-term outcomes ca …