Goldstein LE - Search Results

1

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease.

Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. Kumar DK, et al. Among authors: goldstein le. Sci Transl Med. 2016 May 25;8(340):340ra72. doi: 10.1126/scitranslmed.aaf1059. Sci Transl Med. 2016. PMID: 27225182 Free PMC article.

2

The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.

Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. Huang X, et al. Among authors: goldstein le. Biochemistry. 1999 Jun 15;38(24):7609-16. doi: 10.1021/bi990438f. Biochemistry. 1999. PMID: 10386999

3

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, Bowden EF, Masters CL, Fairlie DP, Tanzi RE, Bush AI. Huang X, et al. Among authors: goldstein le. J Biol Chem. 1999 Dec 24;274(52):37111-6. doi: 10.1074/jbc.274.52.37111. J Biol Chem. 1999. PMID: 10601271 Free article.

4

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.

Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, Huang X, Farrag YW, Perry G, Bush AI. Cuajungco MP, et al. Among authors: goldstein le. J Biol Chem. 2000 Jun 30;275(26):19439-42. doi: 10.1074/jbc.C000165200. J Biol Chem. 2000. PMID: 10801774 Free article.

5

3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.

Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT Jr, Bowden EF, Tanzi RE, Bush AI. Goldstein LE, et al. Biochemistry. 2000 Jun 20;39(24):7266-75. doi: 10.1021/bi992997s. Biochemistry. 2000. PMID: 10852726

6

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Cherny RA, et al. Among authors: goldstein le. Neuron. 2001 Jun;30(3):665-76. doi: 10.1016/s0896-6273(01)00317-8. Neuron. 2001. PMID: 11430801 Free article.

7

Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.

Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT Jr, Bush AI. Goldstein LE, et al. Lancet. 2003 Apr 12;361(9365):1258-65. doi: 10.1016/S0140-6736(03)12981-9. Lancet. 2003. PMID: 12699953

8

RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.

Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. Tucker S, et al. Among authors: goldstein le. Curr Alzheimer Res. 2006 Jul;3(3):221-7. doi: 10.2174/156720506777632835. Curr Alzheimer Res. 2006. PMID: 16842099

9

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD. Soscia SJ, et al. Among authors: goldstein le. PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505. PLoS One. 2010. PMID: 20209079 Free PMC article.

10

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.

Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE. Moncaster JA, et al. Among authors: goldstein le. PLoS One. 2010 May 20;5(5):e10659. doi: 10.1371/journal.pone.0010659. PLoS One. 2010. PMID: 20502642 Free PMC article.

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